TABLE OF CONTENTS Chapter 1 General introduction 7 Part 1: Identifying limited recovery 19 Chapter 2 Patient-reported physical functioning is limited in almost half of critical illness survivors 1-year after ICU-admission: a retrospective single-centre study 21 Chapter 3 The prevalence of mental frailty in ICU-survivors and informal caregiver strain: a 1-year retrospective study of the Frisian aftercare cohort 39 Chapter 4 Long-term health-related quality of life, healthcare utilisation and back-to-work activities in intensive care unit-survivors: prospective confirmatory study from the Frisian aftercare cohort 57 Part 2: Malnutrition and frailty in ICU-patients 77 Chapter 5 The predictive value of phase angle on long-term outcome after ICU-admission 79 Chapter 6 Inadequate protein and energy intake in intensive care unit survivors during the first year of recovery: the Frisian Aftercare cohort study 91 Part 3: Improving recovery after critical illness 109 Chapter 7 The effect of protein provision and exercise therapy on patient-reported and clinical outcomes in ICU-survivors: a systematic review 111 Chapter 8 The feasibility of Virtual Reality therapy for upper extremities mobilisation during and after ICU-admission 175 Chapter 9 Discussion and future perspectives 193 Chapter 10 Nederlandse Samenvatting 207 Chapter 11 Appendices 217
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