52 CHAPTER 3 3.5 SUPPORTING INFORMATION 3.5.1 Supplemental File 1 Supplemental table 1. Mental health and caregiver strain of informal caregivers and patients. Significant differences in bold. Patient mental health No mental frailty Mental frailty p-value HADS, anxiety (0-21) 3-months 2 [1-4] 5 [3-8] <0.001 12-months 2 [1-4] 9 [7-11] <0.001 HADS, depression (0-21) 3-months 2 [0-4] 7 [4-9] <0.001 12-months 3 [1-4] 9 [6-11] <0.001 TSQ (0-10) 3-months 1 [0-2] 2 [1-5] <0.001 12-months 1 [0-2] 4 [2-6] <0.001 Caregiver strain CSI (0-13) 3-months 2 [0-4] 4 [1-6] 0.005 12-months 1 [0-3] 3 [1-6] <0.001 CSI ≥ 7 3-months 16 (11) 18 (20) 0.042 n (%) 12-months 9 (6) 20 (22) <0.001 Caregiver TSQ 3-months 1 [0-3] 2 [0-4] 0.038 (0-10) 12-months 0 [0-2] 1 [0-3] <0.001 Caregiver TSQ ≥ 6 3-months 9 (6) 16 (18) 0.004 n (%) 12-months 4 (3) 15 (17) <0.001
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