44 CHAPTER 3 used in the model to indicate if patients reached cut-off values at 3-months. A second model was analysed using absolute trauma, anxiety, and depression scores at 3-months. The analyses were adjusted for sex, age, and severity of illness (APACHE III). A 2-sided p-value of 0.05 was considered statistically significant for all results. Analyses were performed in IBM SPSS Statistics for Windows, version 27.0 (IBM, NY, USA). Figures were designed using GraphPad Prism, version 9 (GraphPad Software, CA, USA). A size-proportional Venn diagram was made using the online BioVenn tool.21 3.3 RESULTS 3.3.1 Study inclusion and population Of the 250 patients that were eligible for the study, a total of 239 patients completed mental health assessment at 12-months after ICU-discharge (Figure 1). Based on this 12-month assessment, 90 patients (38%) were allocated to the mental frailty group (Table 1). One hundred forty-nine patients were assigned to the group with no mental frailty. There was no difference between groups in sex, age, and severity of illness. Regarding important comorbidities, a difference was found in the total amount of patients with any psychiatric history and specifically in the incidence of pre-existing post-traumatic stress disorder (PTSD). Finally, ICU-characteristics were found to be identical in the two groups. Figure 1. Flowchart of study inclusion No mental frailty, n=149 Mental frailty, n=90 315 Unable/unwilling to visit 23 Deceased within 1 year 3 Incomplete follow up at 12m Received invitation post-ICU clinic, n=591 Patients included in study, n=250 Completed HADS & TSQ at 12m, n=239
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