31 PHYSICAL FUNCTIONING AFTER ICU-ADMISSION 2 at baseline, as well as walking distance, mobility, balance, handgrip strength and physical functioning at 3-months after ICU-admission on the likelihood of recovery of physical functioning at 12-months after ICU-admission. Patients with pre-existing comorbidities may be less likely to improve in physical functioning after 12-months (original data: OR 0.620, CI 0.279–1.377; p = 0.241, corrected for missing values: OR 0.380 CI 0.197-0.734; p = 0.004). A higher balance testing score at 3-months after admission was associated with an increased chance of recovery of physical functioning (original data: OR 1.105 CI 1.025- 0.192; p = 0.009, corrected for missing values: OR 1.066 CI 1.005–1.132; p = 0.034). Finally, a higher RAND-36 physical functioning subscale score at 3-months after ICU-admission increases the likelihood of recovery at 12-months (original data: OR 1.058 CI 1.037–1.080; p < 0.001, corrected for missing values: OR 1.052 CI 1.036–1.069; p < 0.001). The logistic regression model was statistically significant (original data: χ2(3) = 79.1, p < 0.001). The model explained 50.0% (Nagelkerke R2 original data) of the variance in recovery of physical functioning and correctly classified 78.2% of cases. 2.4 DISCUSSION In this retrospective study, a substantial proportion of patients (44%) who visited the standard care post-ICU clinic did not fulfil criteria for full physical recovery at 12-months after ICU-admission. We identified impaired physical functioning at 3-months (assessed as decreased balance and RAND-36 physical functioning subscale scores), as well as the presence of comorbidities at baseline as independent risk factors associated with non-recovery at 12-months. Thus, prediction of further (non-)recovery can only be made with reasonable accuracy 3-months after admission. In contrast, LOS ICU, duration of mechanical ventilation, and renal replacement therapy lost significance in our multivariate model. Moreover, well-established risk factors for hospital mortality, including APACHE III, as well as medical admission type and presence of sepsis, were equal in patients with and without full physical recovery at 12-months. The observed percentage of patients in de NR-group was in line with previous literature. In general, comparison with the existing literature is hampered by differences in HRQoL-scales used, a focus on specific subgroups, and limited follow-up time in small study populations.20 In a comparable Dutch general long-stay ICU-population, SF-36-derived functional status one-year post-ICU was limited in 54 percent of patients, as compared to an age-adjusted reference population.7 Even in a substantially younger Norwegianmixed-ICUpopulation,
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