589448-Beumeler

167 PROTEIN PROVISION AND EXERCISE THERAPY TO IMPROVE OUTCOMES IN ICU-SURVIVORS 7 1 OR adjusted to propensity scores for age, sex, BMI, APACHEII, admission category, traumatic brain injury, history of diabetes sepsis, creatinine and randomisation (to permissive underfeeding or standard feeding). Data not available for N=2. 2 Multiple logistic regression model, adjusted for BMI, ICU geographic region, sex, admission type, age, evaluable days in the ICU, APACHE II, SOFA, and energy intake. Models were not adjusted for NUTRIC score to avoid collinearity since age, APACHE II, and SOFA were included in the NUTRIC score. ICU ≥12 days was used as a subset for sensitivity analysis (results not reported). 3 HR adjusted for age, sex, BMI, APACHE II, diagnostic category. Length of hospital stay as time-dependent variable. Inadequate protein and energy group (iPI/iEI) compared to adequate protein group (aPI). 4 HR adjusted for age, sex, BMI, co-morbidities, and energy or protein intake. 5 Protein in the first 3 days (≤3 days); HR adjusted for other protein sources, weight, age, total calories received, SOFA score, and parenteral nutrition. Protein after first 3 days (>3 days); HR adjusted for age, sex, weight, parenteral nutrition, mean delivered calories, mean daily protein received >3 days, administration of vasopressors, SOFA score, year of study and total hospital stay. 6 Cox regression model; multivariate analysis for relevant variables p<0.10. BMI, SOFA, admission type, hours to start feeding, route of feeding, daily protein target, total protein and caloric intake, adequacy of protein and caloric intake and percentage of non-nutritional calories. Group 1= protein intake <0.8g/ kg/day during whole week. Group 2=initially received <0.8g/kg/day during day 1-3, but advanced to >0.8g/kg/day on day 4. Group 3=protein intake >0.8g/kg/day during whole week.

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