164 CHAPTER 7 7.6.2.7 Appendix 2: Table S4 Table S4. Effects of protein provision on nutritional delivery (mean difference). Author Year Nutritional outcome Time point measured Included in nutrition: EN PN NC PR Azevedo1 2019 protein (g/kg/day) Day 10 X X Fetterplace2 2018 protein (g/kg/day) Day 15 X X X X2 Zanten3 2018 protein (g/kg/day) Mean ICU days X X Zanten3 2018 protein (g/kg/day) Day 5 X X Zanten3 2018 protein (g/kg/day) Day 5 X X Chapple 2020 protein (g/IBWkg/day) Mean day 7-28 X Chapple 2020 protein (g/ABWkg/day) Mean day 7-28 X Chapple 2020 protein (g/ABWkg/day) Mean day 7-28 X X Fetterplace2 2018 protein (g/day) Day 15 X X X X2 Efremov 2017 protein (g/day) Day 7 X X Chapple 2020 energy (kcal/IBWkg/day) Mean day 7-28 X X Fetterplace2 2018 energy (kcal/kg/day) Day 15 X X Fetterplace2 2018 energy (kcal/kg/day) Day 15 X X X X2 Zanten3 2018 energy (kcal/kg/day) Mean ICU days X Azevedo 2019 energy (kcal/day) Day 10 X X Chapple 2020 energy (kcal/day) Mean day 7-28 X X Chapple 2020 energy (kcal/day) Mean day 7-28 X X X Fetterplace2 2018 energy (kcal/day) Day 15 X X X2 Fetterplace2 2018 energy (kcal/day) Day 15 X X X X Efremov5 2017 energy (kcal/day) Day 7 X X Efremov5 2017 energy (kcal/day) Day 7 X X CI: confidence interval. ABW: adjusted body weight. EN: enteral nutrition. g/kg/day: gram per kilogram body weight per day. IBW: ideal body weight. Kcal: kilocalorie. Kcal/kg/day: kilocalorie per kilogram bodyweight per day. MD: mean difference. n: number of participants. NC: non-nutritional kcal, including propofol, dextrose. OR: oral intake. PN: parenteral nutrition. PR: enteral protein supplement. - not reported/unable to retrieve. 1 Intervention: measured resting energy expenditure in kcal/day. Comparator: calculated, 25kcal/kg/ day. Supplemental PN if caloric goals not achieved first 5 days of ICU. 2 IBW if BMI ≥32, <65 years weight of BMI 18.5-25 and ≥65 years BMI 22-27, than IBW+25%. Intervention group received PR. 3 Nutritional delivery averaged over all ICU-days. Energy requirements calculated, 25 kcal/kg/day. N=6 patients received complete or supplemental PN first 5 days. IBW: 30xheight in m2 when BMI ≥30, otherwise ABW. OR intake not fully recorded. 4 Nutritional requirements as per clinician, available for n=95. Calculations based on IBW: men=(height[cm]-152.4)*0.9+50. Women=(height[cm]-152.4)*0.9+45.5. PN was administered if necessary. 5 Measured resting energy expenditure. If EN goal was <60% 74h after surgery, PN was started (80% in intervention and 30% in comparator group received PN). Nutritional requirements not reported (only brand name of EN and PN formulas used).
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