162 CHAPTER 7 7.6.2.6 Appendix 2: Table S3 Table S3. Effects of protein provision on muscle health (mean difference, range). Author Year Outcome Post-intervention or baseline-difference Time point measured Fetterplace1 2018 US QLMT (cm) Baseline-difference ICU-adm.–ICU-discharge/day 15 Fetterplace 218 MUAC (cm) Baseline-difference ICU-adm.–ICU-discharge/day 15 Nakamura 2021 CT FML change (%) Baseline-difference Day 1-10 Ferrie2 2016 US forearmMT (cm) Post-intervention Day 7 Ferrie2 2016 US biceps MT (cm) Post-intervention Day 7 Ferrie2 2016 US thighmuscle area (cm2) Post-intervention Day 7 Ferrie2 2016 US sumof 3 muscle sites (cm) Post-intervention Day 7 Ferrie2 2016 Leg circumference (cm) Post-intervention Day 7 Author Year Outcome Time point measured Wandrag3 2019 US muscle depth change, cm Day 1-7-10 CI: confidence interval. CT: Computed Tomography scan. FML: femoral muscle loss. MD: mean difference. MT: muscle thickness. MUAC: mid-upper arm circumference. n: number of participants. QMLT: quadriceps muscle layer thickness (midpoint and two-third landmarks, mean of 4 linear thicknesses was calculated for each leg separately). US: Ultra Sound technology. - not reported/ unable to retrieve. 1 MD=0.22cm, robust SE 0.08. missing at baseline and discharge in n=6 (23%) in intervention and n=7 (27%) in comparator group. 2 Study results showed p-values for muscle health measures, conducted with analysis of covariance to assess the effect study day 0, 3, and 7, with covariate adjustment including each baseline measure. Missing values were replaced using imputation but results were reported without the replaced value. A total of n=47(39%) and n=7(6%) missing variables for US measurements and leg circumference respectively, with n=25(42%)/n=22(37%) and n=4(57%)/n=3(43%) in intervention/comparator group. 3 50% of measurements completed.
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