160 CHAPTER 7 7.6.2.5 Appendix 2: Table S2 Table S2. Effects of protein provision on physical functioning (mean difference). Author Year Outcome Domain Time point measured Allingstrup1 2017 PCS-SF36 Participation restriction 6-months Azevedo2 2019 PCS-SF36 Participation restriction 6-months Azevedo2 2019 PCS-SF36 Participation restriction 3-months Nakamura 2021 Barthel ADL Index Participation restriction Hospital discharge Wandrag3 2019 Barthel ADL Index Participation restriction ICU-discharge Wandrag3 2019 Katz ADL Participation restriction ICU-discharge Azevedo2 2019 HGS, male (kg) Activity limitation ICU-discharge Azevedo2 2019 HGS, female (kg) Activity limitation ICU-discharge Ferrie4 2016 HGS (kg) Activity limitation ICU-discharge Ferrie4 2016 HGS (kg) Activity limitation Day 7 Fetterplace5 2018 HGS (kg) Activity limitation ICU-discharge/day 15 Fetterplace5 2018 MRC-SS Activity limitation ICU-discharge Fetterplace6 2018 PFIT-score Activity limitation ICU-discharge/day 15 Nakamura 2021 FSS-ICU Activity limitation ICU-discharge CI: confidence interval. Barthel Index: Barthel performance and Activities of Daily Living index (score range: 0-100; higher score is more independent). FSS-ICU: Functional Status Score for the ICU (score range: 0-35; higher is better). HGS: Handgrip strength (expressed in kg; reference values are age and sex dependent). Katz ADL: Katz Activities of Daily Living score (score range: 0-6; higher is more independent). MD: mean difference. MRC-ss: Medical Research Council sum score (score range: 0-60; higher is better). n: number of participants. PCS-SF36: Physical Component Score-Short Form 36 health survey (score range: 0-100; higher score is better). PFIT: Physical Function in Intensive Care Unit test (score range: 0-12; higher is better). - not reported/unable to retrieve. 1 Multiple imputation required, completed questionnaires 51%/54% (intervention/comparator). 2 A score of zero was given at patients who died. Available PCS-SF36 scores (intervention/comparator) at 6-months: n=30(71.4%)/n=31(55.5%) and at 3-months: n=29(52.7%)/n=31 (52.5%). 3 Barthel and Katz ADL scores remained zero throughout the study. 4 Results in table displayed without covariate adjustment for HGS. Missing values assumed missing at random, not replaced (n=7/n=4, intervention/comparator). 5 Missing values of MRC-SS not imputated (77%/53% missing, intervention/comparator). Missing values for HGS and PFIT scores not imputated (80%/47% and 73%/53% missing respectively, intervention/comparator).
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