136 CHAPTER 7 7.6.2 Appendix 2 Appendix 2: supplementary data Supplement 1: search strategy Supplement 2: list of excluded studies with reasons Figure S1: risk of bias (randomised controlled trials) Figure S2: risk of bias (non-randomised trials) Table S1: effects of protein provision on quality of life Table S2: effects of protein provision on physical functioning Table S3: effects of protein provision on muscle health Table S4: effects of protein provision on nutritional delivery Table S5: effects of protein provision on mortality (non-randomised trials) 7.6.2.1 Appendix 2: Supplement 1: search strategy PubMed’s Clinical Study Category search filter (Therapy, Sensitive/broad)1 was used in the search process for both protein provision and combined protein-exercise therapy: ((clinical[Title/Abstract] AND trial[Title/Abstract]) OR clinical trials as topic[MeSH Terms] OR clinical trial[Publication Type] OR random*[Title/Abstract] OR random allocation[MeSH Terms] OR therapeutic use[MeSH Subheading]) Search strategy protein provision Embase (n=3314). Search date: 25-02-2021 (‘critically ill patient’/exp OR ‘intensive care unit’/exp OR ‘critically ill’:ab,ti OR ‘critical ill’:ab,ti OR ‘critical care’:ab,ti OR ‘intensive care’:ab,ti OR ‘intensive care unit’:ab,ti OR ‘mechanically ventilat*’:ab,ti OR ‘mechanical ventilat*’:ab,ti OR ‘invasive ventilat*’:ab,ti) AND (‘nutritional support’/exp OR ‘nutrition supplement’/exp OR ‘protein intake’/exp OR ‘nutritional support’:ab,ti OR ‘dietary intake’:ab,ti OR ‘nutritional management’:ab,ti OR ‘nutritional care’:ab,ti OR ‘artificial feeding’:ab,ti OR ‘enteric feeding’:ab,ti OR ‘enteral feeding’:ab,ti OR ‘enteral nutri*’:ab,ti OR ‘parenteral feeding’:ab,ti OR ‘parenteral nutri*’:ab,ti OR protein*:ab,ti OR ‘amino acid’:ab,ti OR ‘amino acid essential’/exp) NOT ((‘adolescent’/exp OR ‘child’/exp OR adolescent*:ti,ab OR child*:ti,ab OR schoolchild*:ti,ab OR infant*:ti,ab OR girl*:ti,ab OR boy*:ti,ab OR teen:ti,ab OR teens:ti,ab OR teenager*:ti,ab OR youth*:ti,ab OR pediatr*:ti,ab OR paediatr*:ti,ab OR puber*:ti,ab) NOT (‘adult’/exp OR ‘aged’/exp OR ‘middle aged’/exp OR adult*:ti,ab OR man:ti,ab OR men:ti,ab OR woman:ti,ab OR women:ti,ab)) 1 Wilczynski, N. L., McKibbon, K. A. & Haynes, R. B. Sensitive Clinical Queries retrieved relevant systematic reviews as well as primary studies: An analytic survey. J. Clin. Epidemiol. (2011). doi:10.1016/j.jclinepi.2011.04.007
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