118 CHAPTER 7 7.3.2 Characteristics of the studies Study and patient characteristics of included studies are presented in Table 1. The included RCTs were all parallel designs of which four pilot/feasibility studies.47,50,51,54. All NRSI were retrospective cohort studies, one of which was a post-hoc analysis from a larger RCT.56 The majority of the reported ICU-category admissionwas medical; one study included only elective surgical patients.47 The age range of participants was between 47-70 years and BMI between 18.5-32.3 kg/m2. APACHE II and SOFA scores were between 14-25 and Figure 1. Flow diagram of the search process. Flow diagram of the search process. n= the number or reports. *A report could be excluded because of ≥ 1 of the following reasons: 1. Insufficient information on protein delivery or recommendation. 2. No difference in protein recommendation. 3. Other outcome. 4. Not eligible non-randomised controlled trial on intervention effects (NRSI). 5. Other reasons (i.e. trial registration, abstract, no ICUpopulation). Records identified from (CPE) Pubmed (n=130) CENTRAL (n=315) Embase (n=198) (PP) Pubmed (n=2295) CENTRAL (n=1667) Embase (n=3314) Total (n=7919) Records before screening (databases) Duplicate records removed: (n=2962) (additional references) Duplicates removed or marked as ineligible: (n=618) Records identified from Additional references: (n=941) Records screened (n=4957) Reports sought for retrieval (n=512) Reports assessed for eligibility (n=14) Studies included in review (n=1) Reports excluded (n=498) Reports excluded with reasons (n=13) Reports sought for retrieval (n=4445) Reports excluded (n=4338) Reports assessed for eligibility (n=107) Reports excluded with reasons (n=92) Studies included in review (n=15) CPE PP Identification of studies via databases Identification of studies via other methods Identification Screening Included
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