79 ALTERED VISUOMOTOR PROCESSING IN NA 4 Figure 4 Main findings A. Group difference: Healthy > NA TFCE-maps of where NA patients showed significantly less biomechanical complexity-related activity than healthy participants for two contrasts: the interaction between LATERALITY and BIOMECHANICAL COMPLEXITY (BMC) (in light blue, RightBMC > LeftBMC , where the effect of biomechanical complexity is greater for right than for left hands) and the simpler contrast Rightcomplex > Leftcomplex (in green) where right is greater for left on complex trials. NA patients had decreased biomechanical complexity-related activity for their right, affected limb in two clusters; the right extrastriate cortex and bilaterally along the parieto-occipital sulcus. NA patients showed decreased activity in those same regions for right versus left complex trials. B. Biomechanical Complexity Displays how the right extrastriate cluster where healthy > NA (light blue) relates to the right extrastriate body area (dark blue, 8 mm sphere around MNI [50-73 4], Zimmerman et al. 2018) and to the ipsilateral biomechanical complexityrelated activation for right hands (i..e rightcomplex > righteasy) per group (NA in red, healthy in yellow). C. and D. show the boxplots that display the cluster-specific mean z-stat data for the biomechanical complexity effect for left and right hands separately (significant interactions involving group derived from non-parametric TFCE based permutation testing for the contrast RightBMC > LeftBMC, the interaction term of LATERALITY x BIOMECHANICAL COMPLEXITY: R extrastriate cortex: p = 0.011, familywise error corrected, TFCE (peak voxel) = 13544; bilateral parieto-occipital sulcus: p = 0.018, familywise error corrected, TFCE (peak voxel) = 12679) (C.) and for right versus left on complex trials (significant difference derived from non-parametric TFCE based permutation testing for the contrast Rightcomplex > Leftcomplex: R extrastriate cortex: p = 0.027, familywise error corrected, TFCE (peak voxel) = 13167; bilateral parieto-occipital sulcus: p = 0.018, familywise error corrected, TFCE (peak voxel) = 17553) (D.) Boxes represent the interquartile range (IQR) (from the 25th (Q1) to the 75th (Q3) percentile); whiskers show the minimum within Q1-1.5*IQR and the maximum within Q3+1.5*IQR; yellow lines represent the median, yellow plusses the mean; circles are outliers outside Q1/3 -/+ 1.5*IQR. BMC = biomechanical complexity; Left/RightBMC = biomechanical complexity effect for left/right hands; BMC = Biomechanical Complexity; EBA = Extrastriate Body Area; HP = healthy participant; NA = neuralgic amyotrophy; POS = parietooccipital sulcus R = right; TFCE = threshold-free cluster enhancement; Δ = delta; familywise error corrected at p < 0.05. * = significant difference at p < 0.05, familywise error corrected see also Table 2 and Supplementary Table 1 Table 3 Group difference in motor imagery-related activity Table containing information on significant clusters for the interactions between GROUP x LATERALITY x BIOMECHANICAL COMPLEXITY, and GROUP x LATERALITY for complex stimuli only. BMC = Biomechanical Complexity Left/RightBMC = biomechanical complexity effect for left/right hands; L = left; NA = neuralgic amyotrophy; R = right; FWE = familywise error; TFCE = thresholdfree cluster enhancement
RkJQdWJsaXNoZXIy MjY0ODMw