132 CHAPTER 6 To test whether the brain-behavior-symptom correlations we previously reported at baseline (in 39 NA patients, Lustenhouwer et al. 2022) 2 were also present at followup, we tested (one-tailed) whether the difference in RT between right and left complex trials correlated with pain and activity in the parieto-occipital sulcus region of interest, and whether pain correlated with activity in the extrastriate region of interest for both sessions separately. NA patients that had greater difficulty with complex movements of their affected limb (i.e. greater positive difference in reaction time between affected and unaffected limb) also had significantly more pain at both baseline and follow-up, (baseline: rs = 0.35, p = 0.04; follow-up: rs = 0.37, p = 0.03; Supplementary Figure 2A) and significantly reduced activity in the parieto-occipital sulcus when imagining these movements at baseline, but not at follow-up (baseline: rs =-0.40, p = 0.02; follow-up: rs =-0.14, p = 0.25; Supplementary Figure 2B). This partly replicates our previous finding in the full sample of NA patients at baseline. Activity in the right extrastriate region of interest did not correlate significantly with persistent pain at either baseline or follow-up in this subsample (baseline: rs =-0.04, p = 0.43; follow-up: rs = 0.06, p = 0.39). Supplementary Figure 1 Behavior-Symptom-Brain correlations The figure shows the significant correlations between behavior and symptom (A.) and behavior and brain activity (B.) at baseline and at follow-up. Δ Reaction time R-L is the reaction time on right complex trials minus the reaction time on left complex trials. Δ POS activity R-L is brain activity on right vs. left complex trials in the predefined parieto-occipital sulcus region of interest (see also Figure 4B). L = Left; POS = parieto-occipital sulcus; R = right; VAS = Visual Analogue Scale; Δ = delta
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