93 Supplementary Figures Supplementary Figure 1 | A. Antibody-bound peptide PCA after removal of 90 peptides belonging to CMV. B. Density of 2,815 antibody-bound peptide time consistency (same presence status in baseline as in follow-up) in 322 participants after 4 years. C. Correlation plot of highly heritable peptides (H2 ≥ 0.5). Lower triangle shows genetic correlation coefficient estimates. Upper triangle shows presence/absence Pearson’s correlation coefficients. Dot size and color indicate the strength of the correlation. A B −1 −0.8 −0.6 −0.4 −0.2 0 0.2 0.4 0.6 0.8 1 twist_14325 twist_64023 agilent_68956 agilent_84757 twist_88894 twist_44153 twist_29790 twist_29905 agilent_23359 agilent_237643 twist_39975 agilent_134645 agilent_236812 agilent_69695 agilent_11510 twist_30164 agilent_182601 agilent_222726 agilent_222335 agilent_212061 twist_66343 agilent_226736 agilent_8927 agilent_243229 agilent_241884 agilent_220658 agilent_241118 agilent_226247 agilent_4825 agilent_21920 agilent_224401 agilent_231226 agilent_6936 agilent_239239 twist_37560 twist_14325 twist_64023 agilent_68956 agilent_84757 twist_88894 twist_44153 twist_29790 twist_29905 agilent_23359 agilent_237643 twist_39975 agilent_134645 agilent_236812 agilent_69695 agilent_11510 twist_30164 agilent_182601 agilent_222726 agilent_222335 agilent_212061 twist_66343 agilent_226736 agilent_8927 agilent_243229 agilent_241884 agilent_220658 agilent_241118 agilent_226247 agilent_4825 agilent_21920 agilent_224401 agilent_231226 agilent_6936 agilent_239239 twist_37560 −1 0 1 2 3 −2 −1 0 1 2 PC1(3.61%) PC2(1.52%) Cluster 1 2 0 2 4 0.5 0.6 0.7 0.8 0.9 1.0 Consistency density C Determinants of the human antibody epitope repertoire
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