92 Supplementary Tables All supplementary tables are available online via the following link (bioRxiv preprint server): https://www.biorxiv.org/content/10.1101/2021.12.07.471553v1. Supplementary Table 1: Antibody-bound peptide general information. 1.1 Information from 2,815 analyzed peptides, including: database source, amino acid sequence, source protein name, source taxonomy, heritability estimate (H2), co-occurrence module belonging and consistency (after 4 years). 1.2 Left table. Summary of peptides belonging to each of the 22 modules with at least 10 peptides. Right table. General overview of the co-occurrence modules, their category, (1) same taxonomy, (2) ortholog protein, (3) unrelated taxonomy and structure, and the correlation of their eigengenes (PBonferroni<0.05) 1.3 LLD phenotypes, exploratory statistics. Supplementary Table 2. Association analyses summary statistics. 2.1 Antibody-bound peptide among sample dissimilarity (Jaccard) analysis of variability, summary statistics (PERMANOVA, 2,000 permutations). 2.2 GWAS meta-analysis summary statistics (P < 5x10-8). 2.3 HLA associations meta-analysis summary statistics (PBonferroni< 0.05). 2.4 Microbiome taxonomic abundance associations summary statistics (P < 1x10-3). 2.5 Phenotype associations summary statistics (FDR < 0.05). Chapter 3
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