7 Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Introduction to the thesis PART I: IMMUNE-BASED BIOMARKERS IN IBD Antibody signatures in inflammatory bowel disease: current developments and future applications Trends in Molecular Medicine 2022;28(8):693-705. Genetic, environmental and intrinsic determinants of the human antibody epitope repertoire Immunity 2022 (provisionally accepted) In-depth characterization of the serum antibody epitope repertoire in inflammatory bowel disease using phage-display immunoprecipitation sequencing Immunity 2022 (provisionally accepted) Patients with inflammatory bowel disease show IgG immune responses towards specific intestinal bacterial genera Frontiers in Immunology 2022;13:842911. Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease Submitted Part II: INFLAMMATORY - AND FIBROSIS BIOMARKERS IN IBD Increased fecal calprotectin levels in Crohn’s disease correlate with elevated serum Th1- and Th17-associated cytokines PLoS One 2018;13(2):e0193202. A combined set of four serum inflammatory biomarkers reliably predicts endoscopic disease activity in inflammatory bowel disease Frontiers in Medicine 2019;6:251. 13 37 39 65 103 153 183 245 247 263 TABLE OF CONTENTS
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