87 Figure 4 | Phenotype-antibody-bound peptide associations. A. Bar plot displaying the number of associations per phenotype (FDR < 0.05). Phenotypes are grouped in categories. Peptides associated with > 5 phenotypes are grouped. Peptides associated with < 5 phenotypes are labeled ‘Other’. B. Smokinglinked antibody-bound peptide prevalence. X-axis shows prevalence of peptides in smokers. Y-axis shows the prevalence in non-smokers. Colors of dots depict peptide taxonomy. C,D. Autoimmune- and allergyspecific association counts of antibody-bound peptides, per category. Bacterial peptides are binned as “Bacteria”. Viral peptides are binned as “Virus”. Auto-antigens or antigens to casein are binned as “Mammal”. Plant peptides are binned as “Plant”. Anti-SSA: anti–Sjögren’s-syndrome-related antigen A autoantibodies. Anti-CTD: anti-connective tissue diseases screening ratio. Anti-CCP: anti-cyclic citrullinated peptide. 0 100 200 300 400 Bacteria Bacteroidales Bacteroides Clostridiales Enterococcus Enterovirus Escherichia Haemophilus Herpesvirus Influenza Lactobacillus Mammal Mite Parabacteroides Phage Plant Poliovirus Pseudomonadaceae Rhinovirus Staphylococcus Streptococcus Virus Other C D 0.1 0.2 0.3 0.4 0.5 0.2 0.4 0.6 Peptide prevalence Smokers Peptide prevalence non-smokers animal any dust food nasal or hay fever pollen 0 3 6 9 anti-CCP ctd screen ratio anti-SSA 0 5 10 15 20 A B Antibody-bound peptide (N) Antibody-bound peptide (N) Antibody-bound peptide (N) Pets Infancy Health & disease Immune markers Metabolic Allergies Autoimmune Smoking Cell counts Antropometric Determinants of the human antibody epitope repertoire
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