77 0 20 40 60 80 30 50 70 Sex Female Male 4 years participants:1,437 participants:322 26 family trios Age (years) 1e+01 1e+03 1e+05 0 500 1000 1500 2000 Number of samples log10 Number of seroprevalent antibody−bound peptides −1 0 1 −2 −1 0 1 2 PC1(3.51%) PC2(2.84%) Cluster 1 2 0.7 0.8 0.9 0.25 0.50 0.75 Distance (Jaccard) Longitudinal FALSE TRUE Distance (Jaccard) Family relationship unrelated Mother to Father Father to Offspring Mother to Offspring A B C D E Determinants of the human antibody epitope repertoire
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