58 Outstanding Questions What is the exact pathogenic role of aberrant antibody responses in the pathogenesis of IBD? What are the exact microbial or human proteins targeted by antibodies and to which functional consequences do these aberrant immune responses translate in patients with IBD? How do systemic antibody responses in blood relate to mucosal antibody binding in the gut? How do alterations on the DNA level of B cell receptor sequences observed in IBD translate to functional differences in the antigens recognized? What are the clinical implications of these antibody responses for patients with IBD? Which of the state-of-the-art antibody profiling techniques discussed holds the most promise for translation into clinical implementations that might benefit patients with IBD? What methods should be employed for the rational selection of antibody signatures tailored to predict the occurrence of a specific clinical outcome? Chapter 2
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