46 anti-glycan antibodies (summarized in Table 1).3,26,27 These observations may support the notion that microbial antigens are relatively more important in the immunopathogenesis of CD, while autoimmunity is more prominently involved in UC pathogenesis. Thus far, the exact pathogenic role of the specific antibody signatures for CD and UC is largely unknown, but many studies have demonstrated potentially useful associations with clinical phenotypes and outcomes in both types of IBD. Table 1 | Established serological antibodies in IBD. Chapter 2 Table 1. Established serological antibodies in IBD. Serological antibody Description of antigenic target IBD subtype specificity Clinical associations Antimicrobial antibodies ASCA Mannan (cell wall) protein of the yeast Saccharomyces cerevisiae CD Ileal disease involvement, stricturing and penetrating disease, risk of surgery ACCA Chitobioside (cell wall) carbohydrate of yeasts and bacteria CD Steroid dependency, fibrostenotic disease, perianal disease ALCA Laminaribioside (cell wall) carbohydrate of yeasts, bacteria, wheat and algae CD Ileal disease involvement, stricturing and penetrating disease, risk of surgery AMCA Mannobioside (cell wall) carbohydrate of several microorganisms CD Ileal disease involvement, stricturing and penetrating disease, risk of surgery anti-CBir1 Flagellin, flagella component isolated from bacteria in colitis mice CD Ileal disease involvement, stricturing and penetrating disease, long disease duration, early postoperative recurrence Anti-Fla-X Flagellin, Fla-X CD Ileal disease involvement, stricturing disease, perianal disease, early postoperative recurrence Anti-A4-Fla2 Flagellin, A4 strains, frequently linked to Lachnospiraceae family CD Ileal disease involvement, stricturing disease, perianal disease Anti-I2 I2 component of Pseudomonas fluorescens in mucosal mononuclear cells CD Stricturing disease, risk of surgery Anti-L Laminarin CD Steroid dependency, penetrating disease, surgery Anti-C Chitin CD Penetrating disease, surgery anti-OmpC Outer membrane protein of Escherichia coli CD Penetrating disease, risk of surgery anti-MAP Mycobacterium avium subspecies paratuberculosis CD Biological use
RkJQdWJsaXNoZXIy MjY0ODMw