584063-Bourgonje

33 Bernstein CN, Loftus EV Jr, Ng SC, Lakatos PL, Moum B; Epidemiology and Natural History Task Force of the International Organization for the Study of Inflammatory Bowel Disease (IOIBD). Hospitalisations and surgery in Crohn’s disease. Gut 2012;61(4):622-9. doi: 10.1136/gutjnl-2011-301397. Peters V, Spooren CEGM, Pierik MJ, Weersma RK, van Dullemen HM, Festen EAM, et al. Dietary Intake Pattern is Associated with Occurrence of Flares in IBD Patients. J Crohns Colitis 2021;15(8):1305-1315. doi: 10.1093/ecco-jcc/jjab008. Peters V, Bolte LA, Schuttert E, Andreu-Sánchez S, Dijkstra G, Weersma R, et al. Western and carnivorous dietary patterns are associated with greater likelihood of IBD-development in a large prospective population-based cohort. J Crohns Colitis 2021;jjab219. doi: 10.1093/ecco-jcc/jjab219. Opstelten JL, de Vries JHM, Wools A, Siersema PD, Oldenburg B, Witteman BJM. Dietary intake of patients with inflammatory bowel disease: A comparison with individuals from a general population and associations with relapse. Clin Nutr 2019;38(4):1892-1898. doi: 10.1016/j.clnu.2018.06.983. Narula N, Dhillon A, Zhang D, Sherlock ME, Tondeur M, Zachos M. Enteral nutritional therapy for induction of remission in Crohn’s disease. Cochrane Database Syst Rev 2018;4(4):CD000542. doi: 10.1002/14651858. CD000542.pub3. Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW, et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel disease. Nature 2019;569(7758):655-662. doi: 10.1038/ s41586-019-1237-9. Metwaly A, Haller D. Multi-omics in IBD biomarker discovery: the missing links. Nat Rev Gastroenterol Hepatol 2019;16(10):587-588. doi: 10.1038/s41575-019-0188-9. Imhann F, Van der Velde KJ, Barbieri R, Alberts R, Voskuil MD, Vich Vila A, et al. The 1000IBD project: multiomics data of 1000 inflammatory bowel disease patients; data release 1. BMC Gastroenterol 2019;19(1):5. doi: 10.1186/s12876-018-0917-5. Spekhorst LM, Imhann F, Festen EAM, van Bodegraven AA, de Boer NKH, Bouma G, et al. Cohort profile: design and first results of the Dutch IBD Biobank: a prospective, nationwide biobank of patients with inflammatory bowel disease. BMJ Open 2017;7(11):e016695. doi: 10.1136/bmjopen-2017-016695. Manniën J, Ledderhof T, Verspaget HW, Snijder RR, Flikkenschild EF, van Scherrenburg NPC, et al. The Parelsnoer Institute: A National Network of Standardized Clinical Biobanks in the Netherlands. Open J Bioresour 2007;4(1):3. doi: 10.5334/ojb.23. von Martels JZH, Bourgonje AR, Klaassen MAY, Alkhalifah HAA, Sadaghian Sadabad M, Vich Vila A, et al. Riboflavin Supplementation in Patients with Crohn’s Disease [the RISE-UP study]. J Crohns Colitis 2020;14(5):595-607. doi: 10.1093/ecco-jcc/jjz208. Lei L, Sadaghian Sadabad M, Gabarrini G, Lisotto P, von Martels JZH, Wardill HR, et al. Riboflavin supplementation promotes gut microbiota network connectivity and butyrate production in the absence of gross compositional changes. Gut Microbes 2022; submitted manuscript. Otten AT, Bourgonje AR, Peters V, Alizadeh BZ, Dijkstra G, Harmsen HJM. Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut-A Pilot Study. Antioxidants (Basel) 2021;10(8):1278. doi: 10.3390/antiox10081278. Mourits VP, Arts RJW, Novakovic B, Matzaraki V, de Bree LCJ, KoekenVACM, et al. The role of Toll-like receptor 10 in modulation of trained immunity. Immunology 2020;159(3):289-297. doi: 10.1111/imm.13145. Tigchelaar EF, Zhernakova A, Dekens JAM, Hermes G, Baranska A, Mujagic Z, et al. Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics. BMJ Open 2015;5(8):e006772. doi: 10.1136/bmjopen-2014-006772. Hillege HL, Janssen WM, Bak AA, Diercks GF, Grobbee DE, Crijns HJ, et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Intern Med 2001;249(6):519-26. doi: 10.1046/j.13652796.2001.00833.x. 65 66 67 68 69 70 71 72 73 74 75 56 57 78 79 80 General introduction and outline of the thesis

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