327 Collagen biomarkers and Crohn’s disease behavior (A) - A1 (≤ 16 years) 16 (15.8) 7 (18.9) 6 (22.2) 3 (8.1) A2 (17-40 years) 67 (66.3) 23 (62.2) 14 (51.9) 30 (81.1) A3 (> 40 years) 18 (17.8) 7 (18.9) 7 (25.9) 4 (10.8) Montreal Location (L), CD - 0.221 L1 (ileal disease) 31 (30.7) 9 (24.3) 14 (51.9) 8 (21.6) L2 (colonic disease) 15 (14.9) 6 (16.2) 2 (7.4) 7 (18.9) L3 (ileocolonic disease) 54 (53.5) 21 (56.8) 11 (40.7) 22 (59.5) L4 (upper GI disease) 7 (6.9) 5 (13.5) 0 (0.0) 2 (5.4) Montreal Perianal disease (P), CD 31 (30.7) 3 (8.1) 4 (14.8) 24 (64.9) - < 0.001 Medication use, n (%) Total Montreal B1 Montreal B2 Montreal B3 HC P-value Aminosalicylates 7 (6.9) 4 (10.8) 2 (7.4) 1 (2.7) 0.387 Steroids 37 (36.6) 17 (45.9) 10 (37.0) 10 (27.0) 0.240 Immunosuppressives 65 (64.4) 18 (48.6) 20 (74.1) 27 (73.0) 0.043 Prior antiTNF-α 43 (42.6) 15 (40.5) 15 (55.6) 13 (35.1) 0.346 Surgical history - Ileocaecal resection, n (%) 38 (37.6) 4 (10.8) 19 (70.4) 15 (40.5) < 0.001 Colon resection (or partial), n (%) 7 (6.9) 1 (2.7) 1 (3.7) 5 (13.5) 0.139 Clinical disease activity score† Total Montreal B1 Montreal B2 Montreal B3 HC P-value n = 68 n = 28 n = 22 n = 18 HBI 0.638 Remission (< 5) 24 (35.3) 12 (42.9) 6 (27.3) 6 (33.3) Mild disease (5-7) 17 (25.0) 5 (17.9) 8 (36.4) 4 (22.2 Moderate disease (816) 24 (35.3) 9 (32.1) 8 (36.4) 7 (38.9) Severe disease (>16) 3 (4.4) 2 (7.1) 0 (0.0) 1 (5.6) Laboratory parameters - Hemoglobin (mmol/L) 7.7 ± 0.9 7.8 ± 1.0 7.9 ± 0.9 7.6 ± 0.9 0.349 CRP (mg/L) 5.0 [2.1;14.8] 9.6 [4.2;17.8] 2.0 [1.0;5.7] 6.2 [3.2;15.5] 0.003 WBC (x109/L) 7.1 [6.9;9.8] 8.5 [6.5;11.3] 6.4 [4.9;9.2] 6.8 [6.0;9.1] 0.085 Platelets (x109/L) 334 ± 102 366 ± 107 289 ± 82 337 ± 99 0.010 eGFR
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