326 Results Characteristics of the study population Demographic and clinical characteristics of the study population, both for the total cohort (n=101) and separated by disease behavior according to the Montreal classification, are presented in Table 2. A flow diagram of the study patient inclusion can be found in Figure S1. The mean age of the total cohort was 40.5 ± 14.7 years, and proportions of males and females were 37.6% and 62.4%, respectively. Patients with penetrating CD (Montreal B3) more often had perianal disease activity, which frequently co-occurs with this type of disease behavior (P<0.001). Patients with stricturing CD (Montreal B2) more often underwent an ileocaecal resection compared with patients with non-stricturing, non-penetrating (B1) or penetrating (B3) CD (P<0.001), and had lower CRP (P<0.01), platelet counts (P<0.05) and fecal calprotectin (FC) levels (the latter only in a subset of patients, n=38) compared with patients categorized as Montreal B1 or B3. Finally, patients with stricturing and penetrating disease more often used immunosuppressive drugs compared with non-stricturing, non-penetrating CD (P<0.05). The remaining demographic and clinical characteristics were not significantly different between the Montreal classification subgroups. Table 2 | Cohort demographic and clinical characteristics, separated by disease behavior according to the Montreal classification. Chapter 10 Table 2. Cohort demographic and clinical characteristics, separated by disease behavior according to the Montreal classification. Total Montreal B1 Montreal B2 Montreal B3 HC P-value n = 101 n = 37 n = 27 n = 37 n = 96 Age (years) 40.5 ± 14.7 38.5 ± 14.1 45.8 ± 18.1 38.6 ± 11.7 48.9 ± 12.2 0.090 Sex, n (%) 0.102 Male 38 (37.6) 9 (24.3) 13 (48.1) 16 (43.2) 56 (58.3) Female 63 (62.4) 28 (75.7) 14 (51.9) 21 (56.8) 40 (41.7) BMI, kg/m2 25.1 ± 5.3 26.6 ± 6.8 23.4 ± 4.7 24.9 ± 3.4 - 0.055 Smoking, n (%) - 0.055 No 35 (34.7) 16 (43.2) 3 (11.1) 16 (43.2) Previous 31 (30.7) 9 (24.3) 12 (44.4) 10 (27.0) Current 35 (34.7) 12 (32.4) 12 (44.4) 11 (29.7) Montreal classification Montreal Age (A) - 0.164 A1 (≤ 16 years) 16 (15.8) 7 (18.9) 6 (22.2) 3 (8.1) A2 (17-40 years) 67 (66.3) 23 (62.2) 14 (51.9) 30 (81.1) A3 (> 40 years) 18 (17.8) 7 (18.9) 7 (25.9) 4 (10.8) Montreal Location (L), CD - 0.221 L1 (ileal disease) 31 (30.7) 9 (24.3) 14 (51.9) 8 (21.6)
RkJQdWJsaXNoZXIy MjY0ODMw