302 Urinary 52Cr-EDTA/creatinine excretion is highest in CD patients with solely colonic disease No significant differences in 24-h urinary excretion of 52Cr-EDTA/creatinine were observed for subgroups of CD patients with different disease localization according to the Montreal classification (P = 0.270, Figure 2). Still, CD patients with solely colonic disease showed the highest median urinary 52Cr-EDTA/creatinine excretion (791 μmol/mol (IQR: 632-1088), n = 9), whereas median excretion in patients with ileal involvement was lower (ileal disease: 472 μmol/mol (IQR: 312-821), n = 24; ileocolonic disease: 676 μmol/mol (IQR: 417-1006), n = 27, P = 0.093). Figure 2 | Urinary 24-h excretion of 52Cr-EDTA/creatinine for different subgroups of CD patients according to the Montreal classification of disease localization. No significant differences were observed between any groups (P > 0.05). Correlation analysis between urinary 52Cr-EDTA/creatinine excretion and relative abundances of CD-associated bacterial species The absolute and relative abundance of two CD-associated bacteria, F. prausnitzii and Enterobacteriaceae, was quantified by FISH analysis in fecal samples of all patients (see Figure S1 for representative fluorescence microscopy images and Table S1 for quantifications). Among CD patients with below-median and above-median 52Cr-EDTA/creatinine excretion, there were no significant differences detected in relative abundances (%) of F. prausnitzii and Enterobacteriaceae. Interestingly, we observed a borderline non-significant negative correlation between 24-h urinary 52Cr-EDTA/creatinine excretion and relative numbers of F. prausnitzii (ρ = -0.221, P = 0.092, Figure 3A). In contrast, a moderately positive correlation, though non-significant, was found between 24-h urinary 52Cr-EDTA/creatinine excretion and relative numbers of Enterobacteriaceae species (ρ = 0.202, P = 0.126, Figure 3B). Chapter 9
RkJQdWJsaXNoZXIy MjY0ODMw