281 predictive performances compared to CRP, fecal calprotectin and HBI/SCCAI scores. The best prediction of luminal disease activity was observed when SAA, IL-6, IL-8 and Eotaxin-1 were combined, which, as a relatively small panel of biomarkers, harbors great potential to improve monitoring of intestinal inflammatory activity and therapeutic efficacy in IBD. Author Contributions AB, JvM, RG, KF and GD were involved in conceptualization and study design. GD and KF were responsible for funding acquisition and resources. GD obtained approval from the medical ethical board. AB, JvM, RG, HvD, EF, RS, MV, RW, KF and GD collected all study data. AB performed data curation, data analysis and visualization. AB, JvM and RG wrote the first draft of the manuscript. PV, KF and GD contributed to results interpretation and critically reviewed the manuscript. All authors contributed to manuscript revision, read and approved the final version of the manuscript. Conflicts of Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Funding Disclosures The research position of AB is supported by a JSM M.D.-Ph.D. trajectory grant (Grant No: 17-57) from the Junior ScientificMasterclass of the University of Groningen, the Netherlands. The research position of JvM is financed by the Top Institute of Food and Nutrition (TIFN) in Wageningen and the Center for Development & Innovation of the University Medical Center Groningen (UMCG), the Netherlands. Predicting endoscopic disease activity in IBD
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