277 In the CD subgroup, regarding the predictive value for SES-CD scored endoscopic disease activity, serum levels of SAA presented the best discriminative capacity as represented by an AuROC of 0.79 (SE: 0.09, 95% CI: 0.61 – 0.96 , P < 0.01) (Supplementary Figure S7). In the UC subgroup, the combination of IL-6 and Eotaxin-1 demonstrated the best predictive performance (AuROC 0.97, SE: 0.03, 95%CI: 0.92 – 1.02, P < 0.001) (Supplementary Figure S8). Detailed subgroup analyses for both CD and UC cohorts are described in the supplementary data (Supplementary Figure S7 and S8). Figure 4 (A-D) | Areas under the receiver operating characteristics curve (AuROC) for (A) the best predictive combination of biomarkers (serum amyloid A (SAA), interleukin-6 (IL-6), interleukin-8 (IL-8) and Eotaxin-1) (n = 64), (B) serum C-reactive protein (CRP) levels, (C) fecal calprotectin (FC) levels (μg/g) (n = 25) and (D) Harvey Bradshaw Index (HBI) or Simple Clinical Colitis Activity Index (SCCAI) (n = 56). Predicting endoscopic disease activity in IBD
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