273 Predicting endoscopic disease activity using inflammatory biomarkers To test the predictive performances of selected inflammatory biomarkers, distributions of serum concentrations of all biomarkers were compared between IBD patients with binary categorized, composite IBD endoscopic disease activity: remission (0) or mild (1) endoscopic disease activity vs. moderate (2) or severe (3) endoscopic disease activity (Supplementary Table S4). Subsequently, subgroup analyses were performed for CD and UC patients separately, which can be found in the Supplementary Material (Supplementary Table S5 and Supplementary Figures S2-S5). Using the composite IBD endoscopy score, patients with high endoscopic disease activity (either moderate (2) or severe (3)) demonstrated significantly elevated serum concentrations of Eotaxin-1, SAA, TNF-α, IL-6, IL-8 and IL-17A as compared to patients with low endoscopic disease activity (either remission (0) or mild (1)) (Figure 2). In the CD subgroup, using the binary ordered SES-CD, significantly increased concentrations of SAA, IFN-γ, IL-6 and IL-17A were observed in patients with high endoscopic disease activity (Supplementary Table S5; Supplementary Figure S2). In UC, using the binary Mayo endoscopic subscore categories, serum concentrations of IL6, TNF-α and Eotaxin-1 were significantly increased in moderate-to-severe disease activity as compared to remission or mild disease activity (Supplementary Table S5; Supplementary Figure S4). To evaluate their predictive accuracies with respect to endoscopically active disease, receiver operating characteristics (ROC) curves were established (Figure 3). In the ROC analysis, serum levels of Eotaxin-1 (pg/ml) and SAA (mg/l) presented the best discriminative capacity regarding binary ordered, composite IBD endoscopic disease activity (area under the receiver operating characteristics curve (AuROC) 0.75 (SE: 0.06, 95% CI: 0.62 – 0.87, P < 0.001) for both serum Eotaxin-1 and SAA levels) (Table 3). Serum levels of IL-17A, IL-8, IL-6 and TNF-α were of subordinate, but still reasonable discriminative value. Predicting endoscopic disease activity in IBD
RkJQdWJsaXNoZXIy MjY0ODMw