270 Table 1 | Median (IQR) of baseline serum concentrations of all detected molecules in CD (n = 64) and UC (n = 54) patients as compared to healthy controls (HC) (n = 20). Data are presented as median (IQR). Differences between groups were tested using Kruskal-Wallis tests. P-values < 0.05 were considered statistically significant (Bonferroni-adjusted). Figure 1 (A-H) | Serum levels of selected inflammatory biomarkers in Crohn’s disease (CD) (n = 64) and ulcerative colitis (UC) (n = 54) patients and healthy controls (HC) (n = 20). (A) Serum CRP levels (mg/l) are significantly increased in CD as compared to UC and healthy controls. (B) Serum SAA levels (mg/l) are significantly increased in IBD as compared to healthy controls. (C) Serum IFN-γ levels (pg/ml) are significantly more elevated in CD as in UC. (D) Serum IL-6 levels (pg/ml) are significantly increased in CD as compared to UC and healthy controls. (E) Serum IL-8 levels (pg/ml) are specifically more elevated in UC as compared to CD and HC. (F) Serum IL-10 levels (pg/ml) are also significantly increased in UC as compared to CD or HC. (G) Serum IL-17A levels (pg/ml) are strongly significantly increased in both CD and UC as compared to HC. (H) Serum Eotaxin-1 levels (ng/ml) are significantly elevated in UC as compared to CD, but comparable with that of HC. *P-values < 0.05 were considered statistically significant. **P < 0.01. ***P < 0.001. Table 1. Median (IQR) of baseline serum concentrations of all detected molecules in CD (n = 64) and UC (n = 54) patien s as compared o healthy controls (HC) (n = 20). Data are presented as median (IQR). Detected molecules CD UC HC P-value CRP (mg/l) 8.17 (2.42 – 17.3) 3.37 (0.86 – 9.48) 1.11 (0.71 – 3.08) < 0.001 SAA (mg/l) 6.53 (3.31 – 14.5) 8.75 (2.85 – 40.9) 3.41 (1.67 – 5.12) 0.005 IFN-γ (pg/ml) 8.68 (5.03 – 16.1) 5.29 (3.67 – 8.04) 6.23 (5.03 – 8.40) 0.007 TNF-α (pg/ml) 2.15 (1.71 – 2.84) 2.29 (1.42 – 3.39) 2.12 (1.81 – 2.47) 0.578 IL-6 (pg/ml) 0.91 (0.69 – 1.92) 0.72 (0.40 – 1.46) 0.49 (0.38 – 0.62) < 0.001 IL-8 (pg/ml) 6.16 (4.62 – 9.36) 8.42 (5.51 – 13.0) 5.47 (4.61 – 6.50) 0.005 IL-10 (pg/ml) 0.41 (0.28 – 0.51) 0.61 (0.34 – 1.58) 0.31 (0.22 – 0.41) 0.004 IL-17A (pg/ml) 2.30 (1.24 – 3.26) 2.76 (1.94 – 5.07) 1.04 (0.94 – 1.36) < 0.001 Eotaxin-1 (ng/ml) 0.20 (0.16 – 0.29) 0.28 (0.20 – 0.36) 0.28 (0.23 – 0.33) 0.018 Eotaxin-3 (pg/ml) 17.0 (12.4 – 23.6) 19.2 (14.5 – 22.6) 19.6 (13.3 – 29.6) 0.454 Differences between groups were tested using Kruskal-Wallis tests. P-values < 0.05 were considered statistically significant (Bonferroni-adjusted). Chapter 8
RkJQdWJsaXNoZXIy MjY0ODMw