253 Table 2. Median (IQR) of serum levels of all detected molecules (pg/mL) in Crohn’s disease patients with ‘normal’ (< 200 mg/kg) and increased (> 200 mg/kg) fecal calprotectin levels. Detected molecules Calprotectin < 200 mg/kg Calprotectin > 200 mg/kg P-value Pro-inflammatory panel IFN-γ 7.80 (4.09-19.72) 23.00 (10.13-38.72) < 0.05* IL-1β 0.05 (0.04-0.08) 0.05 (0.03-0.13) 0.945 IL-2 0.18 (0.12-0.23) 0.17 (0.10-0.25) 0.932 IL-4 0.04 (0.02-0.07) 0.04 (0.03-0.06) 0.777 IL-6 0.78 (0.39-1.15) 1.29 (0.93-1.88) < 0.01** IL-8 11.91 (7.20-15.43) 12.63 (6.35-68.62) 0.955 IL-10 0.32 (0.19-0.44) 0.37 (0.24-0.74) 0.321 IL-12p70 0.09 (0.03-0.26) 0.07 (0.04-0.18) 0.624 IL-13 0.56 (0.42-0.91) 0.77 (0.55-1.79) 0.153 TNF-α 3.13 (2.50-3.67) 3.49 (2.82-4.79) 0.095 Cytokine panel GM-CSF 0.16 (0.07-0.29) 0.15 (0.07-0.24) 0.784 IL-5 0.26 (0.16-0.57) 0.26 (0.19-0.54) 0.883 IL-7 19.95 (13.57-28.08) 18.93 (10.18-27.09) 0.552 IL-12/23p40 118.18 (74.94-204.08) 158.38 (125.23-222.36) 0.157 IL-15 3.04 (2.31-5.66) 2.87 (2.44-5.74) 0.777 IL-16 284.06 (203.49-316.63) 285.97 (195.06-327.77) 0.755 IL-17A 5.25 (3.04-9.27) 8.22 (5.11-11.85) 0.058 TNF-β 0.49 (0.34-0.55) 0.55 (0.42-0.66) 0.051 Chemokine panel Eotaxin 266.32 (179.61-351.18) 240.14 (190.62-356.28) 0.955 MIP-1β 90.12 (73.41-172.00) 80.40 (47.64-129.26) 0.322 Eotaxin-3 20.29 (15.72-30.32) 15.57 (11.79-22.39) 0.101 TARC 242.32 (138.99-512.79) 267.11 (156.86-359.57) 0.799 IP-10 2.99x103 (2.40x1034.62x103) 3.60x103 (2.25x1034.66x103) 0.590 MIP-1α 16.27 (13.31-20.75) 16.75 (12.69-24.30) 0.966 MCP-1 217.13 (166.20-357.20) 261.95 (188.06-357.75) 0.630 MDC 1.33x103 (1.02x1031.69x103) 1.28x103 (1.07x1031.66x103) 0.977 Angiogenesis panel VEGF 469.52 (236.89-726.63) 382.16 (223.83-896.71) 0.755 VEGF-C 569.55 (442.96-737.47) 462.11 (375.45-628.34) 0.141 VEGF-D 1.07x103 (770.27-1.47x103) 901.29 (799.81-1.41x103) 0.777 Tie-2 804.11 (652.49-969.74) 708.28 (626.90-845.61) 0.213 Flt-1 147.69 (126.14-167.65) 144.15 (129.16-171.30) 0.932 PIGF 6.28 (5.45-7.40) 5.80 (5.10-7.85) 0.876 bFGF 5.08 (2.05-21.97) 9.12 (2.29-27.11) 0.745 Vascular injury panel SAA 4.78x106 (2.84x106- 8.87x106) 9.02x106 (4.64x106- 2.87x107) < 0.05* CRP 1.25x106 (6.03x105- 4.67x106) 6.79x106 (3.61x106- 2.64x107) < 0.01** VCAM-1 8.28x105 (7.83x1059.64x105) 8.91x105 (7.67x1051.02x106) 0.671 ICAM-1 4.97x105 (4.27x1056.00x105) 5.63x105 (4.99x1057.06x105) 0.062 Table 2 | Median (IQR) of serum levels of all detected molecules (pg/mL) in Crohn’s disease patients with ‘normal’ (< 200 mg/kg) d increas d (> 200 mg/kg) fecal calprot ctin levels. *P-value < 0.05 was considered statistically significant; **P-value < 0.01. Inflammatory proteins in Crohn’s disease
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