22 Table 1. Overview of cohorts/biobanks and corresponding data and/or biomaterials used for the studies as presented in this thesis. Cohort/Biobank Participants Number (n) Data/biomaterials used or collected Relevant to chapters: 1000IBD cohort, UMCG, the Netherlands IBD patients 1,000-1,200 WES, GSA, proteomics, bulk RNAseq, fecal metagenomics, metabolomics, mucosal 16S rRNA seq, PhIP-seq, clinical data, dietary data, environmental data 3,4,6,1113,18,19 Dutch IBD Biobank or ‘Parelsnoer’, the Netherlands (nationwide) IBD patients 1,000-1,500 Serum, plasma, clinical data 5,7-10,1618,28,30 Infliximab (IFX) cohort IBD patients 70-100 Serum, plasma, clinical data 23-26 Vedolizumab (VEDO) cohort IBD patients 50-80 Serum, plasma, clinical data 23-26 RISE-UP study, UMCG CD patients 79 Serum, plasma, urine, fecal metagenomics, FISH 22 Ribogut study, UMCG Healthy volunteers 99 Serum, plasma, fecal metagenomics, FISH 21 Vitamin C study, UMCG Healthy volunteers 20 Fecal 16S rRNA gene sequencing 20 LifeLines(-DEEP), Groningen Population individuals 167,000 (total) 1,443 (LLDEEP) PhIP-seq, fecal metagenomics, WES/GSA, plasma, phenotypic data 3,4,5,19 PREVEND study, UMCG Population individuals 8,592 (total) Serum, plasma, urine, clinical data 15 300BCG study, Radboud UMC Healthy volunteers 148 Plasma, clinical data 11 COVID-HOME, UMCG Population individuals >200 Serum/plasma, clinical data 29 Abbreviations: GSA, global screening array; FISH, fluorescence in-situ hybridization; IBD, inflammatory bowel disease; PREVEND, PhIP-seq, phage-display immunoprecipitation sequencing; Prevention of Renal and Vascular ENd-stage Disease; UMCG, University Medical Center Groningen; WES, whole-exome sequencing. CD who received riboflavin (vitamin B2) supplementation in the ‘RISE-UP’ clinical trial. 75 Similarly, two other intervention cohorts consisting of healthy volunteers were newly established and used to study health effects of vitamin B2 and vitamin C supplementation in the ‘Ribogut-study’ and vitamin C-study, respectively.76,77 Finally, four cohorts of healthy volunteers or populationbased individuals have been used in this thesis, either serving as control cohorts (300BCG and LifeLines-DEEP) or as exploratory cohorts with longitudinal (follow-up) data (PREVEND and COVID-HOME).78-81 Table 1 | Overview of cohorts/biobanks and corresponding data and/or biomaterials used for the studies as presented in this thesis. Abbreviations: GSA, global screening array; FISH, fluorescence in-situ hybridization; IBD, inflammatory bowel disease; PREVEND, PhIP-seq, phage-display immunoprecipitation sequencing; Prevention of Renal and Vascular ENd-stage Disease; UMCG, University Medical Center Groningen; WES, whole-exome sequencing. Chapter 1
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