231 Extended Data Figure S5 Extended Data Figure S5 | Composition of the mucosal microbiota is highly personalized and influenced by disease parameters and clinical factors in patients with IBD and controls. (A) Hierarchical clustering analysis demonstrating that tissue samples from the same individual (paired samples) clearly cluster together (colors indicate unique individuals). (B) Hierarchical analysis performed using an end-to-end statistical algorithm (HAllA) showing the main phenotypic factors that correlate with intestinal mucosal microbiota composition. Heatmap color palette indicates normalized mutual information. Numbers and dots in cells identify the significant pairs of features (phenotypic factors vs. bacterial taxa) in patients with IBD and controls. Abbreviations: BMI, body-mass index; CD, Crohn’s disease; UC, ulcerative colitis. SRR6704325 SRR6704385 SRR6704388 SRR6704377 SRR6704378 SRR6704308 SRR6704309 SRR6704310 SRR6704312 SRR6704313 SRR6704262 SRR6704260 SRR6704261 SRR6704303 SRR6704304 SRR6704305 SRR6704279 SRR6704280 SRR6704259 SRR6704258 SRR6704263 SRR6704243 SRR6704359 SRR6704382 SRR6704322 SRR6704323 SRR6704251 SRR6704249 SRR6704250 SRR6704288 SRR6704281 SRR6704287 SRR6704398 SRR6704257 SRR6704397 SRR6704315 SRR6704286 SRR6704285 SRR6704314 SRR6704402 SRR6704390 SRR6704391 SRR6704248 SRR6704271 SRR6704341 SRR6704292 SRR6704406 SRR6704340 SRR6704343 SRR6704332 SRR6704264 SRR6704265 SRR6704266 SRR6704267 SRR6704379 SRR6704401 SRR6704413 SRR6704345 SRR6704370 SRR6704371 SRR6704316 SRR6704317 SRR6704347 SRR6704348 SRR6704352 SRR6704366 SRR6704311 SRR6704318 SRR6704353 SRR6704354 SRR6704375 SRR6704376 SRR6704272 SRR6704273 SRR6704350 SRR6704394 SRR6704245 SRR6704300 SRR6704301 SRR6704328 SRR6704335 SRR6704384 SRR6704276 SRR6704277 SRR6704358 SRR6704268 SRR6704278 SRR6704253 SRR6704254 SRR6704400 SRR6704403 SRR6704380 SRR6704387 SRR6704393 SRR6704238 SRR6704351 SRR6704396 SRR6704404 SRR6704346 SRR6704369 SRR6704372 SRR6704373 SRR6704329 SRR6704330 SRR6704319 SRR6704331 SRR6704374 SRR6704407 SRR6704241 SRR6704244 SRR6704246 SRR6704334 SRR6704284 SRR6704357 SRR6704324 SRR6704412 SRR6704356 SRR6704408 SRR6704274 SRR6704275 SRR6704282 SRR6704283 SRR6704383 SRR6704386 SRR6704306 SRR6704307 SRR6704270 SRR6704289 SRR6704290 SRR6704291 SRR6704256 SRR6704389 SRR6704409 SRR6704298 SRR6704299 SRR6704269 SRR6704295 SRR6704294 SRR6704297 SRR6704296 SRR6704368 SRR6704321 SRR6704361 SRR6704362 SRR6704239 SRR6704240 SRR6704338 SRR6704339 SRR6704242 SRR6704320 SRR6704326 SRR6704327 This study HMP2 A B Mucosal host-microbe interactions in IBD
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