220 Ahmadian R, Suh JM, Hah N, Liddle C, Atkins AR, Downes M, et al. PPARγ signaling and metabolism: the good, the bad and the future. Nat Med 2013;19(5):557-66. doi: 10.1038/nm.3159. Dubuquoy L, Rousseaux C, Thuru L, Peyrin-Biroulet L, Romano O, Chavatte P, et al. PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut 2006;55(9):1341-9. doi: 10.1136/gut.2006.093484. Peyrin-Biroulet L, Beisner J, Wang G, Nuding S, Oommen ST, Kelly D, et al.Peroxisome proliferatoractivated receptor gamma activation is required for 28 maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A 2010;107(19):8772-7. doi: 10.1073/pnas.0905745107. Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motooka D, et al. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 2016;532(7597):117-21. doi: 10.1038/ nature17406. Burkhardt AM, Tai KP, Flores-Guiterrez JP, Vilches-Cisneros N, Kamdar K, Barbosa-Quintana O, et al. CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity. J Immunol 2012;188(12):6399-406. doi: 10.4049/jimmunol.1102903. Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, et al. Control of endodermal endocrine development by Hes-1. Nat Genet 2000;24(1):36-44. doi: 10.1038/71657. Katoh M, Katoh M. Notch signaling in gastrointestinal tract (review). Int J Oncol 2007;30(1):247-51. Ma S, Shungin D, Mallick H, Schirmer M, Nguyen LH, Kolde R, et al. Population Structure Discovery in Meta-Analyzed Microbial Communities and Inflammatory Bowel Disease. bioRxiv 2020; doi: 10.1101/2020.08.31.261214. Limketkai BN, Akobeng AK, Gordon M, Adepoju AA. Probiotics for induction of remission in Crohn’s disease. Cochrane Database Syst Rev 2020;7(7):CD006634. doi: 10.1002/14651858.CD006634.pub3. Jakubczyk D, Leszczyńska K, Górska S. The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)-A Critical Review. Nutrients 2020;12(7):1973. doi: 10.3390/nu12071973. Rieder F, Fiocchi C, Rogler G. Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases. Gastroenterology 2017;152(2):340-350.e6. doi: 10.1053/j. gastro.2016.09.047. Rieder F. The gut microbiome in intestinal fibrosis: environmental protector or provocateur? Sci Transl Med 2013;5(190):190ps10. doi: 10.1126/scitranslmed.3004731. Siva S, Rubin DT, Gulotta G, Wroblewski K, Pekow J. Zinc Deficiency is Associated with Poor Clinical Outcomes in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis 2017;23(1):152-157. doi: 10.1097/MIB.0000000000000989. Ananthakrishnan AN, Khalili H, Song M, Higuchi LM, Richter JM, Chan AT. Zinc intake and risk of Crohn’s disease and ulcerative colitis: a prospective cohort study. Int J Epidemiol 2015;44(6):1995-2005. doi: 10.1093/ije/dyv301. Dai H, Wang L, Li L, Huang Z, Ye L. Metallothionein 1: A New Spotlight on Inflammatory Diseases. Front Immunol 2021;12:739918. doi: 10.3389/fimmu.2021.739918. Jalanka J, Salonen A, Salojärvi J, Ritari J, Immonen O, Marciani L, et al. Effects of bowel cleansing on the intestinal microbiota. Gut 2015;64(10):1562-8. doi: 10.1136/gutjnl-2014-307240. Imhann F, van der Velde KJ, Barbieri R, Alberts R, Voskuil MD, Vich Vila A, et al. The 1000IBD project: multiomics data of 1000 inflammatory bowel disease patients; data release 1. BMC Gastroenterol 2019;19(1):5. Heida FH, van Zoonen AGJF, Hulscher JBF, Te Kiefte BJC, Wessels R, Kooi EMW, et al. A Necrotizing Enterocolitis-Associated Gut Microbiota Is Present in the Meconium: Results of a Prospective Study. Clin Infect Dis 2016;62(7):863-870. Bartram AK, Lynch MDJ, Stearns JC, Moreno-Hagelsieb G, Neufeld JD. Generation of multimillionsequence 16S rRNA gene libraries from complex microbial communities by assembling paired-end illumina reads. Appl Environ Microbiol 2011;77(11):3846-52. Chapter 6 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101
RkJQdWJsaXNoZXIy MjY0ODMw