193 ● ● ● ● ● ● ● ● ● 5 10 15 20 Dissimilarities P=7.79x10-27 P=4.08x10-17 Inter-colon Inter-ileum Intra ● ●● −10 −5 0 5 −10 −5 0 5 10 PC1 PC2 ● ● 0 1 2 3 CD UC Control shannon P=2.75x10-12 P=0.09 P=0.03 A B C D E CD UC Non-IBD ● ● ● ● ● ● ● ● ● 0 5 10 15 20 25 CD UC Control P=3.44x10-18 P=1.08x10-21 P=2.9x10-34 Dissimilarities CD UC Non-IBD Dissimilarities P=9.37x10-28 ● ● ● ● ● 5 10 15 20 P=7.90x10-18 Dissimilarities P=3.94x10-22 ● ● ● ● ● ● ● ● ● ● ● 5 10 15 20 25 Freq P=6.79x10-18 Montreal B1 vs. B2 Montreal E CD vs. non-IBD UC vs. non-IBD CD vs. UC Anti-TNF therapy Age Montreal A Ruminococcus_1 CAG.56 Ruminiclostridium_9 Ruminococcus_2 Bilophila Coprobacter GCA. 900066575 Butyricicoccus Prevotella_9 Phascolarctobacterium Clostridium_sensu_stricto_1 Collinsella Dialister Oscillibacter Veillonella Lachnospiraceae_ND3007_group Akkermansia Christensenellaceae_R.7_group Parasutterella Ruminiclostridium_6 Coprococcus_3 Ruminococcaceae_UCG.013 Campylobacter Fusobacterium Ruminococcaceae_UCG.005 Flavonifractor Lachnospiraceae_UCG.010 Lachnospiraceae_NK4A136_group Ruminococcaceae_UCG.002 Fusicatenibacter Lachnospira Subdoligranulum Haemophilus Anaerostipes Agathobacter Roseburia Faecalibacterium Lachnoclostridium
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