187 Mucosal host-microbe interactions in IBD Female 374 (53.7) 120 (56.6) 240 (56.1) 14 (25.0) BMI (kg/m2) 25.7 ± 4.5 25.7 ± 4.6 25.7 ± 4.7 24.7 ± 2.5 Current smoking, n (%) 0.01 Yes 145 (20.8) 37 (17.5) 88 (20.6) 20 (35.7) No 551 (79.2) 175 (82.5) 340 (79.4) 36 (64.3) Montreal classification Montreal Age (A), n (%) 638 (99.7) 212 (100) 426 (99.5) - 0.95 A1 (≤16 years) 73 (11.4) 23 (10.8) 50 (11.7) - A2 (17–40 years) 397 (62.0) 132 (62.3) 265 (62.2) - A3 (>40 years) 168 (26.3) 57 (26.9) 111 (26.1) - Montreal Location (L), n (%) 333 (94.9) 108 (94.7) 225 (94.9) - 0.83 L1 (ileal disease) 66 (19.8) 18 (16.7) 48 (21.3) - L2 (colonic disease) 51 (15.3) 17 (15.7) 34 (15.1) - L3 (ileocolonic disease) 172 (51.7) 58 (53.7) 114 (50.7) - L1 + L4 12 (3.6) 3 (2.8) 9 (4.0) - L2 + L4 6 (1.8) 3 (2.8) 3 (1.3) - L3 + L4 26 (7.8) 9 (8.3) 17 (7.6) - Montreal Behavior (B), n (%) 333 (94.9) 108 (94.7) 225 (94.9) - 0.31 B1 (non-stricturing, nonpenetrating) 146 (43.8) 53 (49.1) 93 (41.3) - B2 (stricturing) 59 (17.7) 20 (18.5) 39 (17.3) - B3 (penetrating) 30 (9.0) 9 (8.3) 21 (9.3) - B1 + P (perianal disease) 35 (10.5) 10 (9.3) 25 (11.1) - B2 + P (perianal disease) 48 (14.4) 15 (13.9) 33 (14.7) - B3 + P (perianal disease) 15 (4.5) 1 (0.9) 14 (6.2) - Montreal Extension (E), n (%) 246 (85.1) 83 (84.7) 163 (85.3) - 0.95 E1 (proctitis) 19 (7.7) 7 (8.4) 12 (7.4) - E2 (left-sided colitis) 75 (30.5) 25 (30.1) 50 (30.7) - E3 (pancolitis) 152 (61.8) 51 (61.4) 101 (62.0) - Montreal Severity (S), n (%) 207 (71.6) 68 (69.4) 139 (72.8) 0.70 S0 (remission) 11 (5.3) 3 (4.4) 8 (5.8) S1 (mild) 28 (13.5) 9 (13.2) 19 (13.7) S2 (moderate) 109 (52.7) 33 (48.5) 76 (54.7) S3 (severe) 59 (28.5) 23 (33.8) 36 (25.9) Medication use Aminosalicylates, n (%) 271 (42.3) 91 (42.9) 180 (42.1) - 0.87 Thiopurines, n (%) 210 (32.8) 66 (31.1) 144 (33.6) - 0.53 Steroids, n (%) 262 (40.9) 105 (49.5) 157 (36.7) - <0.01 Methotrexate, n (%) 44 (6.9) 18 (8.5) 26 (6.1) - 0.32 TNF-α-antagonists, n (%)† 113 (17.7) 35 (16.5) 78 (18.4) - 0.58 Clinical disease activity HBI 324 (92.3) 104 (91.2) 220 (92.8) - 0.18 Remission (<5) 205 (63.3) 60 (57.7) 145 (65.9) -
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