186 Results Cohort description Demographic and clinical characteristics of the study population are presented in Table 1. In total, we included 640 intestinal biopsies from 337 patients with IBD and 56 intestinal biopsies from 16 non-IBD controls. Biopsies were derived from the colon (64.4%) and ileum (35.6%), and patients with CD and UC were equally represented among inflamed (CD: 53.8%, UC: 46.2%) and noninflamed (CD: 55.4%, UC: 44.6%) biopsies. Mean age and the proportion of smokers were higher among controls (P<0.01 and P=0.01, respectively). Among biopsies derived from patients with IBD, the proportion of steroid users was higher among patients from whom inflamed biopsies were collected (P<0.01). Remaining patient characteristics were evenly distributed among groups without significant differences. Table 1 | Demographic and clinical characteristics of the study population compared between the inflamed and non-inflamed dataset. Chapter 6 Table 1. Demographic and clinical characteristics of the study population compared between the inflamed and non-inflamed dataset. Variable Total IBD Non-IBD Controls Pvalue Inflamed biopsies Noninflamed biopsies n = 696 n = 212 n = 428 n = 56 Biopsy inflammation, n (%) Inflamed 212 (30.5) 212 (100) - - Non-inflamed 428 (61.5) - 428 (100) - Biopsy location, n (%) <0.01 Ileum 248 (35.6) 66 (31.1) 173 (40.4) 9 (16.1) Colon 448 (64.4) 146 (68.9) 255 (59.6) 47 (83.9) Diagnosis or control, n (%) 0.74 CD 351 (50.4) 114 (53.8) 237 (55.4) - UC 289 (41.5) 98 (46.2) 191 (44.6) - Controls 56 (8.0) - - 56 (100) Age at biopsy (years) 43.1 ± 15.3 43.0 ± 15.8 42.3 ± 15.5 45.5 ± 10.8 <0.01 Sex, n (%) Male 322 (46.3) 92 (43.4) 188 (43.9) 42 (75.0) Female 374 (53.7) 120 (56.6) 240 (56.1) 14 (25.0) BMI (kg/m2) 25.7 ± 4.5 25.7 ± 4.6 25.7 ± 4.7 24.7 ± 2.5 Current smoking, n (%) 0.01 Yes 145 (20.8) 37 (17.5) 88 (20.6) 20 (35.7) No 551 (79.2) 175 (82.5) 340 (79.4) 36 (64.3) Montreal classification Montreal Age (A), n (%) 638 (99.7) 212 (100) 426 (99.5) - 0.95 A1 (≤16 years) 73 (11.4) 23 (10.8) 50 (11.7) - A2 (17–40 years) 397 (62.0) 132 (62.3) 265 (62.2) - A3 (>40 years) 168 (26.3) 57 (26.9) 111 (26.1) -
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