172 Conflicts of Interest GD and HJMH received an unrestricted research grant from Royal DSM. GD received speaker fees from Pfizer, Abbvie and Janssen Pharmaceuticals. All other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Author Contributions HJMH and GD were involved in conceptualization and study design. HJMH and GD were responsible for funding acquisition and resources. GRB, MS, HJHM, and GD collected all study data. ARB, GRB, PL, MS, RDR, MCdG and HJMH performed data curation, data analysis, and visualization. ARB, GRB and HJMH wrote the first draft of the manuscript. All authors contributed to results interpretation, critically reviewed the manuscript, contributed to manuscript revision, and read and approved the final version of the manuscript. Funding The research position of ARB was supported by a JSMM.D.-Ph.D. trajectory grant (grant no: 17-57) from the Junior Scientific Masterclass (JSM) of the University of Groningen, the Netherlands. The funders had no role in the design of the study, collection, analysis, or interpretation of data, nor in writing of the manuscript. Acknowledgments The authors would like to express their gratitude towards all patients and healthy volunteers who participated in this study. The authors would also like to thank Carien Bus-Spoor, Joy Volkerink, Rudi Tonk, Tim Stobernack, and Solomon Mekonnen for their contributions to this study. Data Availability The datasets generated for this study are available on request to the corresponding author. Chapter 5
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