167 Table 2. Paired analysis of mean bacterial abundances (>0.25) in original, untreated fecal samples versus IgG-coated fecal samples. Data are presented as mean bacterial abundances (>0.25) sorted in descending order for patients with IBD. *P-values for Wilcoxon’s signed rank tests. #Bacterial genera that were differentially abundant between IBD and HC. Abbreviations: HC, healthy controls; IBD, inflammatory bowel disease; ns, not significant. Table 2. Paired analysis of mean bacterial abundances (>0.25) in original, untreated fecal samples versus IgG-coated fecal samples. Genus Family HC IBD Average Change P-value* Average Change P-value* Blautia Lachnospiraceae 11.17 -0.79 ns 13.28 -3.19 0.003 Streptococcus# Streptococcaceae 0.81 +1.47 <0.001 9.74 +4.79 <0.001 Bifidobacterium Bifidobacteriaceae 6.16 +1.27 ns 7.67 -1.96 ns Ruminococcus gnavus-like Lachnospiraceae 2.71 +2.52 <0.001 7.11 +0.80 0.035 Coprococcus Lachnospiraceae 4.53 +4.39 <0.001 5.45 +4.26 <0.001 Faecalibacterium Ruminococcaceae 9.42 -3.34 <0.001 4.80 -3.40 <0.001 Roseburia Lachnospiraceae 5.07 -2.46 <0.001 4.28 -2.81 <0.001 Dorea Lachnospiraceae 1.30 +1.69 <0.001 3.28 +2.97 <0.001 Escherichia coli-like Enterobacteriaceae 0.20 +0.03 ns 2.37 -0.67 0.003 Lactobacillus# Lactobacillaceae 0.12 +0.08 0.003 1.99 +0.39 <0.001 Eubacterium Erysipelotrichaceae 0.78 +0.50 ns 1.58 -0.01 0.015 Dialister Veillonellaceae 1.69 +0.44 0.02 1.45 +1.16 <0.001 Clostridium Clostridiaceae 0.51 +0.29 0.008 0.99 +0.54 ns Bacteroides Bacteroidaceae 3.46 -2.87 <0.001 0.95 -0.54 <0.001 Enterococcus Enterococcaceae 0.42 +0.17 <0.001 0.70 +0.54 ns Akkermansia Verrucomicrobiaceae 0.31 -0.01 ns 0.70 -0.21 ns Collinsella Coriobacteriaceae 0.59 +0.29 0.016 0.64 -0.05 ns Veillonella Veillonellaceae <0.01 +0.03 <0.001 0.48 +0.07 0.003 Lactococcus# Streptococcaceae 0.07 -0.02 ns 0.45 +0.08 <0.001 Oscillospira Ruminococcaceae 1.76 -0.00 ns 0.44 +0.05 ns Turicibacter Erysipelotrichaceae 0.13 +0.13 <0.001 0.25 +0.30 <0.001 Data are presented as mean bacterial abundances (>0.25) sorted in descending order for patients with IBD. *P-values for Wilcoxon’s signed rank tests. #Bacterial genera that were differentially abundant between IBD and HC. Abbreviations: HC, healthy controls; IBD, inflammatory bowel disease; ns, not significant.
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