164 Figure 2 (A-B) | Principal coordinate analysis (PCoA) of fecal samples from patients with IBD (orange) and HC (blue) visualizing the beta-diversity of the gut microbiota as represented by Bray-Curtis dissimilarities. (A) Sample origin (IBD vs. HC) shows an evident separation of the first two principal coordinates, which was statistically confirmed (PCoA1 and PCoA2: P<0.001). (B) Paired analysis of IgG-coated vs. untreated fecal samples showed no significant change in the first two principal coordinates. Sample origin (IBD vs. HC) and sample handling (IgG-coated vs. untreated samples) significantly explained 20.5% and 2.2% of the variation in the gut microbiota, respectively. Abbreviations: HC, healthy control; IBD, inflammatory bowel disease; MACS, magnetic-activated cell sorting; PCoA1, principal coordinate 1; PCoA2, principal coordinate 2.
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