145 Supplementary Figure S4 | Microbial dysbiosis largely determines variation in fecal metagenomics data and is a hallmark of IBD. (A) Principal component analysis (PCA) demonstrating that study cohort (IBD vs. LLD healthy individuals) significantly associates with the first two PCs. (B–C) Patients with IBD demonstrate higher dysbiosis scores compared to healthy individuals (B), whereas there are no notable differences between IBD subtypes (CD, UC and IBD-U) (C). The antibody epitope repertoire in IBD
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