128 Figure 6 | Ileal and stricturing CD disease phenotypes show distinct antibody responses against specific Lachnospiraceae flagellins. (A) A distinct cluster of antibody-bound peptides (orange-red dots) clearly separates patients with ileal disease involvement (Montreal L1/L3, CD) from patients with IBD with solely colonic disease involvement (Montreal L2 for CD and Montreal E for UC). (B) Patients with CD with a stricturing disease phenotype (Montreal B2) demonstrate characteristic antibody responses against a few specific bacterial flagellins. Abbreviations: CD, Crohn’s disease; FDR, false discovery rate; IBD, inflammatory bowel disease; Montreal B1, non-stricturing, non-penetrating CD; Montreal B2, stricturing CD. Chapter 4
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