127 In patients with stricturing CD (Montreal classification category B2, n = 80), 12 different antibody-bound peptides were significantly enriched compared to patients with non-stricturing, non-penetrating CD (Montreal category B1, n = 141) (FDR < 0.05) (Figure 6B, Table S15). All of these peptides originated from bacterial flagellins, especially those from anaerobic, butyrateproducing bacteria, including Roseburia spp., A. rectalis, Lachnospira pectinoschiza, Eubacterium spp. and undefined Lachnospiraceae. In addition, a few peptides from flagellins of Clostridium spp. and L. pneumophila were among those differentially enriched in patients with stricturing CD. Together, these 12 antibody-bound peptides were all overrepresented in patients with ileal disease involvement (and were all among the 59 differentially abundant peptides between ileal and colonic IBD, Table S14). However, only these 12 differentially abundant antibody-bound peptides demonstrated moderate accuracy to differentiate between patients with stricturing CD from those with non-stricturing, non-penetrating CD (AUC = 0.69, Figure 6B). The antibody epitope repertoire in IBD
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