120 Figure 3 | Distinct antibody epitope repertoires in patients with IBD compared to healthy individuals. (A) Case–control analysis of patients with IBD and healthy individuals, controlling for age, gender and plate ID, revealed 373 differentially abundant peptides (blue Venn diagram) in patients with IBD compared to healthy controls. Of these, 202 peptides were overrepresented in patients with IBD (green Venn diagram), whereas 171 peptides were underrepresented (red Venn diagram). (B) Differentially abundant antibody-bound peptides between patients with CD and UC compared to healthy controls (FDR < 0.05, logistic regression analysis, see Tables S3–5 for full lists of differentially enriched peptides). Abbreviations: CD, Crohn’s disease; FDR, false discovery rate; HCs, healthy controls; UC, ulcerative colitis. Chapter 4
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