Thesis

87 5 Salivary flow versus PROs The association between total salivary flow and subscales of the EORTC QLQ-H&N35 and GRIX showed no significant differences at M0 (Table 4). At M3, weak significant differences were found for dry mouth (Spearman’s ρ=-0.339, p=0.004) and sticky saliva (Spearman’s ρ=-0.321, p=0.006) on the EORTC QLQ-H&N35, and for xerostomia during the day (Spearman’s ρ=-0.332, p=0.006) on the GRIX questionnaire. At M6, weak significant differences were found for the item sticky saliva (Spearman’s ρ=-0.350, p=0.006) on the EORTC QLQ-H&N35 and for the item sticky saliva during the day (Spearman’s ρ=-0.348, p=0.006) on the GRIX questionnaire. A moderate correlation was found for the item xerostomia during the day (Spearman’s ρ=-0.441, p=0.001) on the GRIX questionnaire. As example, Figure 2d displays xerostomia during the day versus total saliva at M6. Correlations between total salivary flow and all items of the EORTC QLQ-H&N35 and SWALQOL can be found in Appendices 7 and 8, respectively. Table 4. Spearman correlation coefficients of salivary flow versus the EORTC QLQ-H&N35 and GRIX *: p<0.05, †: p≤0.006 (Bonferroni correction), M0: before treatment, M3: 3 months after treatment, M6: 6 months after treatment Total salivary flow M0 (n = 45) M3 (n = 65) M6 (n = 57) EORTC QLQH&N35 Spearman’s ρ p-value Spearman’s ρ p-value Spearman’s ρ p-value Dry mouth -0.227 0.126 -0.339 0.004*† -0.279 0.031* Sticky saliva -0.217 0.143 -0.321 0.006*† -0.350 0.006*† GRIX Xerostomia during day -0.254 0.092 -0.332 0.006*† -0.441 0.001*† Xerostomia during night -0.147 0.329 -0.225 0.063 -0.099 0.450 Xerostomia total score -0.182 0.232 -0.327 0.008* -0.320 0.015* Sticky saliva during day -0.218 0.151 -0.282 0.019* -0.348 0.006*† Sticky saliva during night -0.299 0.044* -0.192 0.115 -0.128 0.331 Sticky saliva total score -0.271 0.072 -0.274 0.023* -0.256 0.048*

RkJQdWJsaXNoZXIy MjY0ODMw