29 2 Outcome mean (SD) Pre-Tx: 76.9 (25.3) Post-Tx: 52.6 (16.0) p<0.001 ±1 year: I:62 (SE 5), II:44 (SE 6), p=0.01 ±2 years: I:59 (SE 5), II:43 (SE 5), p=0.03 I:65 (24.2), II:40 (21.1), p=0.024 57.1 (17.9) I:69 (18.3), II:57 (19.3), p=0.039 75 (32) I:75 (35), II:80 (32), III:69 (25) I:86.1 (22.7), II:71.0 (24.8), p=0.001 Post-operative: 31.9 (26.9) 79.2 (25.2) I:85.3, II:50.0, p=0.01 IV:81 (25), V:75 (27), p=0.58 Timing of assessment in m (range) 12 I:16 (IQR 12-23) & 28 (IQR 23-35) II:15 (IQR 12-20) & 26 (IQR 22-33) I:40.6 (10-60) II:27.9 (8-54) 64.3 (20-93) ≥12 8.5 (IQR 4-13.5) 12 One day preoperatively, ½, 1, 3, 6, 9, 12 41.1 (6-88) I:39.2 II:32.5 III:63.7 Treatment (n) Wide local excision, HG with SND, FPND, RT SND, soft FF (I:39, II:32), composite FF (I:25, II:23), adj. RT Mandible res. (I:3, II:3), FPND, soft tissue radial rec.(RFFF(20)), adj. RT(I:4, II:5) Partial mandible res. (10), segm. res. (1), PG and limited FOM res. (12), SG and total FOM excision (9), uni- or bilateral ND (SND(18), MRND(3)), PORT(6) No or marginal mandibulectomy (I:18, II:19), segm. Mandibulectomy (I:2, II:10), PORT (I:10, II:17) Res. with SOND, local flap, FF or PMMF, free fibula bone graft, PORT (13) Res. with or without submandibular gland preservation, flap rec. (I:2, II:12) Res., rec. with distant (8) or local (7) flap FOM res., PG, marginal mandibulectomy, ND, rec. with thigh STSG, adj. RT (I:5, II:1, III:2) N stage (n) N0 N0: I:53, II:41 N1: I:10, II:9 N2+: I:6, II:10 N/A N/A N/A N0: 54 N0: I:36, II:131 N0: 14 N2: 1 N0: I:8, II:3, III:1 N1: I:2, III:1 N2: I:2, II:1, III:1 T stage (n) T1-2: 39 T3-T4: I:44, II:38 N/A T2: 5 T3: 5 T4: 11 T2: I:1, II:4 T3: I:7, II:12 T4: I:12, II:13 T1: 29 T2: 25 T1: I:14, II:56 T2: I:22, II:75 Tis: 1 T1: 6 T2: 4 T4: 4 T1: I:12, II:3, III:3 T2: I:5, II:1 Site (n) T(39) B(23), FOM(40), G(24), T(29), other(13) Anterior FOM (I:5, II:4), B and FOM and G and T(I:5, II:6) FOM(8),T(13) B(I:2, II:4), FOM(I:4, II:6), G(I:8, II:8), L(I:2, II:6), T(I:4, II:5) B(54) T(I:15, II:51), B(I:9, II:35), G(I:7, II:23), FOM(I:5, II:22) FOM(4), A(4), B(2), T(3), L(1), P(1) Lateral FOM (I:17), anterior FOM (II:4), alveolar ridge with FOM(III:3) Age mean (SD) (range) in y 51.62 (21.23) I:61 (11) II:60 (12) 55.6 (43-72) I:59.3 (45-72) II:51.9 (43-65) 53.1 (41-69) I:73.8 (70-83) II:73.5 (70-89) 44 (11) (18-70) I:48.6 II:53.4 60 (13.2) (46-94) 66.8 I:65.7 II:65.8 III:74.3 n (%male) 39 (87) I:69 (38) II:60 (43) 20 (70) I:10 (70) II:10 (70) 21 (100) 49 (78) I:20 (75) II:29 (79) 54 (87) I:26 II:15 III:13 I:36 (63.9) II:131 (76.3) 15 (66) 24 (66) I:17 (35) II:4 (50) III:3 (100) IV:16 V:8 Sub-groups N/A I: no RT II: RT I: LSM II: V/MLR N/A I: FF rec. II: no FF rec. I:T1 without RT II:T2 without RT III:T1 and T2 with RT I:ND with submandibular gland preservation II: conventional ND N/A I: lateral FOM II: anterior FOM III: alveolar ridge with FOM IV: No RT V: RT Type L, P L, R C, P C, P C, R C C, R L, R C Location IN UK UK CHN CHN IN CHN G US Author 1. Argawal et al. (2014) 2. Bekiroglu et al. (2011) 3. Devine et al. (2001) 4. Fang et al. (2013) 5. Fang et al. (2014) 6. Ghai et al. (2021) 7. Gu et al. (2021) 8. Hoene et al. (2021) 9. Larson et al. (2021) Table 1. Demographic, tumor and treatment related details of reviewed

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