Thesis

151 *: p<0.10; CI: Confidence Interval, CRT: Chemo radiation, PO: Post-operative, RT: Radiotherapy, SWAL-QOL: Swallowing Quality of Life questionnaire Estimated eating duration =47.66 - 4.15male - 7.56no weight loss - 0.10(1-5kg weight loss) - 11.23non smoker – 8.01 former smoker – 11.01tumor stage1 - 7.72tumor stage2 + 2.39tumor stage3 + 8.15M3 + 6.67M6 + 1.33M12 + 6.11M24 - 8.56hypopharynx&larynx – 5.35oropharynx + 6.82RT + 2.93CRT + 2.77Surgery&(C)RT – 10.97hypopharynx&larynx*M3 – 12.84hypopharynx&larynx*M6 - 7.35hypopharynx&larynx*M12 - 12.59hypopharynx&larynx*M24 + 0.50oropharynx*M3 – 4.30oropharynx*M6 - 5.18oropharynx*M12 – 9.81oropharynx*M24 + 9.95RT*M3 + 11.78RT*M6 + 9.32 RT*M12 + 9.58RT*M24 + 18.79CRT*M3 + 19.40CRT*M6 + 17.46CRT*M12 + 17.85CRT*M24 + 24.28Surgery&(C)RT*M3 + 20.64Surgery&(C)RT*M6 + 22.39Surgery&(C)RT*M12 + 18.48Surgery&(C)RT*M2 8 p-value 0.016* 0.076* 0.068* 0.002* <0.001* M24 Estimate (95% CI) -12.59 (-22.81 to -2.36) -9.81 (-20.65 to 1.04) 9.58 (-0.71 to 19.86) 17.85 (6.58 to 29.12) 18.48 (8.14 to 28.82) p-value 0.141 0.328 0.066* 0.002* <0.001* M12 Estimate (95% CI) -7.35 (-17.15 to 2.44) -5.18 (-15.57 to 5.21) 9.32 (-0.61 to 19.25) 17.46 (6.67 to 28.25) 22.39 (12.56 to 32.22) p-value 0.006* 0.386 0.013* <0.001* <0.001* M6 Estimate (95% CI) -12.84 (-21.99 to -3.69) -4.30 (-14.01 to 5.42) 11.78 (2.46 to 21.10) 19.40 (9.24 to 29.56) 20.64 (11.59 to 29.69) p-value 0.005* 0.904 0.013* <0.001* <0.001* M3 Estimate (95% CI) -10.97 (-18.71 to -3.24) 0.50 (-7.67 to 8.67) 9.95 (2.08 to 17.82) 18.79 (10.15 to 27.43) 24.28 (16.67 to 31.89) M0 Estimate (95% CI) Reference Reference Reference Reference Reference Reference Reference 0.053* 0.242 0.142 0.584 0.543 -8.56 (-17.24 to 0.12) -5.35 (-14.31 to 3.61) Reference Reference 6.82 (-2.30 to 15.95) 2.93 (-7.56 to 13.42) 2.77 (-6.17 to 11.71) Table 2 (continued) Hypopharynx and larynx Oropharynx Oral cavity CO2 laser or surgery RT CRT Surgery with PO(C)RT Tumor site Treatment

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