147 8 Table 1. Characteristics of patients that were included in the NET-QUBIC study, patients included in the linear mixed model analyses and patients that responded to the SWAL-QOL questionnaire (responders) at baseline (M0) p-value Variables Total NETQUBIC study n = 739 n (%) Patients included in LMM analyses n = 603 n (%) Responders M0 n = 553 n (%) Total NETQUBIC study versus patients included in LMM analyses Total NETQUBIC study versus responders M0 Age mean (SD) 63.3 (9.7) 63.5 (9.5) 63.5 (9.6) 0.602† 0.637† Sex 0.943ǂ 0.860ǂ Male 549 (74.3) 449 (74.5) 410 (74.1) Female 190 (25.7) 154 (25.5) 143 (25.9) Tumor site 0.927ǂ 0.837ǂ Oropharynx 262 (35.5) 217 (36.0) 201 (36.3) HPV positive 130 (49.6) 114 (52.5) 106 (52.7) 0.425ǂ 0.679ǂ HPV negative 99 (37.8) 74 (34.1) 68 (33.8) Missing 33 (12.6) 29 (13.4) 27 (13.4) Larynx or hypopharynx 257 (34.8) 210 (34.8) 191 (34.5) Oral cavity 199 (26.9) 176 (29.2) 161 (29.1) Unknown primary 21 (2.8) 0 0 Tumor stage 0.562ǂ 0.715ǂ 1 163 (22.1) 150 (24.9) 139 (25.1) 2 132 (17.9) 113 (18.7) 105 (19.0) 3 127 (17.2) 98 (16.3) 88 (15.9) 4 317 (42.9) 242 (40.1) 221 (40.0) Primary treatment 0.831ǂ 0.901ǂ RT 241 (32.6) 199 (33.0) 189 (34.2) CRT 215 (29.1) 163 (27.0) 147 (26.6) Surgery or CO2 laser 152 (20.6) 133 (22.1) 121 (21.9) Surgery with PO(C)RT 129(17.4) 107 (17.7) 96 (17.3) Other 2 (0.3) 1 (0.2) 0 Alcohol consumption 0.999ǂ 0.991ǂ Drink regularly 313 (42.4) 302 (50.1) 298 (53.9) Seldom drink 170 (23.0) 164 (27.2) 164 (29.7) Drank in past 88 (11.9) 85 (14.1) 85 (15.4) Missing 168 (22.7) 52 (8.6) 6 (1.0) Smoking 0.997ǂ 0.982ǂ Nonsmoker 105 (14.2) 101 (16.7) 100 (18.1) Former smoker 321 (43.4) 311 (51.6) 309 (55.9) Smoker 146 (19.7) 140 (23.2) 139 (25.1) Missing 168 (22.7) 51 (8.5) 5 (0.9) Comorbidity 0.907ǂ 0.731ǂ None 204 (27.6) 177 (29.4) 164 (29.7) Mild 264 (35.7) 218 (36.2) 203 (36.7) Moderate 155 (21.0) 119 (19.7) 108 (19.5) Severe 76 (10.3) 61 (10.1) 52 (9.4) Missing 40 (5.4) 28 (4.6) 26 (4.7) Weight loss 0.945ǂ 0.745ǂ No weight loss 471 (63.7) 386 (64.0) 357 (64.6) 1-5 kg 121 (16.4) 96 (15.9) 88 (15.9) >5 kg 71 (9.6) 55 (9.1) 48 (8.7) Missing 76 (10.3) 66 (11.0) 60 (10.8) *: p-value <0.05; †: ANOVA, ǂ: Chi-square CRT: Chemo radiation, LMM: Linear Mixed Model, PO: post-operative, RT: Radiotherapy, SD: Standard deviation, SWAL-QOL: Swallowing Quality of Life questionnaire
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