130 Interactions with timing of assessment M24 p-value <0.001* 0.002* 0.552 Estimate (95% CI) -3.23 (-4.96 to -1.49) -3.09 (-5.00 to -1.18) -0.79 (-3.38 to 1.81) M12 pvalue 0.200 0.088* 0.112 Estimate (95% CI) -1.06 (-2.69 to 0.56) -1.55 (-3.32 to 0.23 1.99 (-0.46 to 4.44) M6 pvalue 0.021* 0.019* 0.630 Estimate (95% CI) -1.78 (-3.29 to -0.27) -2.01 (-3.68 to -0.33) 0.53 (-1.62 to 2.67) M3 pvalue 0.052* 0.064* 0.956 Estimate (95% CI) -1.77 (-3.55 to 0.02) -1.83 (-3.76 to 0.11) -0.07 (-2.53 to 2.39) M0 Estimate (95% CI) Reference Reference Reference Reference pvalue 0.011* 0.043* 0.211 0.001* 0.021* 0.711 0.392 0.761 Estimate (95% CI) 1.46 (-2.40 to 5.32) Reference 1.97 (0.47 to 3.48) 1.30 (0.04 to 2.56) 0.86 (-0.49 to 2.22) 2.49 (1.03 to 3.95) 0.07 (0.01 to 0.13) Reference -0.33 (-2.09 to 5.32) 0.84 (-1.09 to 2.77) -0.36 (-2.72 to 1.99) M0 M3 M6 M12 M24 Surgery RT CRT Surgery with (C)RT Intercept Timing of assessment Age Treatment Table 3. Linear mixed model estimates for the number of swallows *: p<0.10, CI: Confidence interval, CRT: Chemoradiotherapy, SE: Standard Error, RT: Radiotherapy The following formula for the estimated number of swallows shows the variables and their coefficients. Factors with a positive coefficient will increase the number of swallows and therefore reflect a worse swallowing function: Estimated number of swallows = 1.46 + 1.97M3 + 1.30M6 + 0.86M12 + 2.49M24 + 0.07age - 0.33RT + 0.84CRT - 0.36surgery with (C)RT - 1.77RT*M3 – 1.83CRT*M3 - 0.07surgery with (C)RT*M3 -1.78RT*M6 – 2.01CRT*M6 + 0.53surgery with (C)RT*M6 - 1.06RT*M12 - 1.55CRT*M12 + 1.99surgery with (C)RT*M12 - 3.23RT*M24 - 3.09CRT*M24 - 0.79surgery with (C)RT*M24
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