113 6 Table 2. Linear mixed model estimates for the MAT *: p<0.10; SE: Standard Error The following formula for the estimated MAT shows the significant variables and their coefficients that were retained in the model. Factors with a coefficient above 0 will increase the MAT outcome and therefore indicate a worse masticatory performance: Estimated MAT = 15.40 + 0.08age - 2.63tumorstage1 - 1.97tumorstage2 + 0.25tumorstage3 + 2.14M3 + 1.49M6 - 0.13M12 - 0.40M24 - 1.21oropharynx – 0.13hypopharynx&larynx – 2.48oropharynx*M3 – 2.03hypopharynx&larynx*M3 – 1.78oropharynx*M6 – 1.08hypopharynx&larynx*M6 – 0.83oropharynx*M12 + 0.69hypopharynx&larynx*M12 + 0.15oropharynx*M24 + 0.48hypopharynx&larynx*M24 p-value 0.874 0.634 Interactions with timing of assessment M24 Estimate (95% CI) 0.15 (-1.74 to 2.04) 0.48 (-1.51 to 2.47) p-value 0.326 0.438 M12 Estimate (95% CI) -0.83 (-2.49 to 0.83) 0.69 (-1.06 to 2.44) p-value 0.020* 0.181 M6 Estimate (95% CI) -1.78 (-3.29 to -0.28) -1.08 (-2.67 to 0.50) p-value <0.001* 0.005* M3 Estimate (95% CI) -2.48 (-3.80 to -1.15) -2.03 (-3.45 to -0.61) M0 Estimate (95% CI) Reference Reference Reference p-value 0.008* 0.001* 0.018* 0.801 <0.001* 0.014* 0.840 0.613 0.166 0.878 Estimate (95% CI) 15.40 0.08 (0.02 to 0.14) -2.63 (-4.23 to -1.03) -1.97 (-3.59 to -0.35) 0.25 (-1.73 to 2.24) Reference Reference 2.14 (1.08 to 3.21) 1.49 (0.31 to 2.67) -0.13 (-1.45 to 1.18) -0.40 (-1.94 to 1.15) Reference -1.21 (-2.94 to 0.51) -0.13 (-1.87 to 1.60) 1 2 3 4 M0 M3 M6 M12 M24 Oral cavity Oropharynx Hypopharynx and larynx Intercept Age Tumor stage Timing of assessment Tumor site
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