93 Markers of neurodegeneration in subjective cognitive decline Figure 3. Kaplan Meier curves visualizing clinical progression within AN classification Kaplan Meier curves visualizing clinical progression to mild cognitive impairment or dementia for different definitions of neurodegeneration (A, total tau (t-tau); B, medial temporal atrophy (MTA); C, hippocampal volume, threshold 25th percentile (HV 25); D, neurofilament light, threshold 75th percentile (NFL 75); E, glial fibrillary acidic protein, threshold 75th percentile (GFAP 74)). Survival is visualized by constructing a four-level variable of dichotomous amyloid and neurodegeneration status (A-N-, A-N+, A+N-, A+N+). 4
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