Thesis

92 Chapter 4 Table 4. Risk of mild cognitive impairment or dementia for dichotomous N biomarkers Biomarker n Model 1 Model 2 Model 3 Model 4 T-tau 401 4.95 (2.99 - 8.22) a,b 3.68 (2.16 - 6.25) a,b 2.47 (1.40 - 4.36) a,b MTA 364 1.74 (0.98 - 3.08) 0.90 (0.47 - 1.71) 0.84 (0.42 - 1.66) 0.85 (0.43 - 1.68) HV 25 361 2.60 (1.49 - 4.54) a,b 2.03 (1.13 - 3.67) a,b 2.22 (1.22 - 4.04) a,b 2.27 (1.24 - 4.16) a,b 10 361 1.94 (0.91 - 4.12) 1.31 (0.57 - 3.01) 1.89 (0.84 - 4.26) 1.96 (0.87 - 4.39) NfL 75 296 3.50 (2.00 - 6.11) a,b 1.98 (1.04 - 3.78)a 1.40 (0.73 - 2.68) 1.42 (0.74 - 2.71) 90 296 2.54 (1.30 - 4.96) a,b 1.48 (0.72 - 3.04) 1.04 (0.51 - 2.11) 1.07 (0.53 - 2.17) GFAP 75 296 4.01 (2.26 - 7.10) a,b 2.32 (1.20 - 4.49) a,b 1.10 (0.53 - 2.29) 1.03 (0.49 - 2.16) 90 296 4.69 (2.52 - 8.74) a,b 2.89 (1.48 - 5.66) a,b 1.68 (0.86 - 3.27) 1.68 (0.87 - 3.25) Abbreviations: GFAP = glial fibrillary acidic protein; HV = hippocampal volume; MTA = medial temporal atrophy; NfL = neurofilament light; t-tau = total tau. Data shown are hazard ratio (95% confidence interval) as estimated by Cox proportional hazards analyses (outcome: clinical progression to mild cognitive impairment or dementia). Predictors: model 1: dichotomized N biomarker; model 2: dichotomized N, age and sex; model 3: dichotomized A, N, age and sex; model 4: dichotomized A, T, N, age and sex. In models with MTA and HV, scanner type was additionally added as covariate. MTA = medial temporal atrophy, HV 25 = hippocampal volume, threshold 25th percentile, HV 10 = hippocampal volume, threshold 10th percentile, NfL 75 = neurofilament light, threshold 75th percentile, NfL 90 = neurofilament light, threshold 90th percentile, GFAP 75 = glial fibrillary acidic protein, threshold 75th percentile, GFAP 90 = glial fibrillary acidic protein, threshold 90th percentile. T-tau was not entered in model 4 due to collinearity between t-tau and phosphorylated tau. a p <0.05. b False discovery rate-corrected p <0.05.

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