TABLE OF CONTENTS CHAPTER 1 General introduction 7 CHAPTER 2 ATN classification and clinical progression in subjective cognitive decline: The SCIENCe project 21 CHAPTER 3 Grey zone amyloid burden affects memory function: the SCIENCe project 57 CHAPTER 4 Association of CSF, blood and imaging markers of neurodegeneration with clinical progression in people with subjective cognitive decline 79 CHAPTER 5 Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score 105 CHAPTER 6 Cerebral blood flow, amyloid burden and cognition in cognitively normal individuals 131 CHAPTER 7 Longitudinal change in ATN biomarkers in cognitively normal individuals 155 CHAPTER 8 Summary and general discussion 179 APPENDIX Nederlandse samenvatting List of publications List of affiliations List of theses of the Alzheimer Center Dankwoord About the author 193 206 209 213 218 220
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